Although many people have received information about liposomal supplements, most of them still think about whether they are just propaganda or really exist. And! We tell you they are genuine. Take, for example, Liposomal vitamin C, about whom so much has been said. It is assimilated up to 5 times more successfully than any other form of vitamin C. Liposomal goods are compressed in a fatty substance that surrounds it and makes it additionally soluble in fat and freely assimilated from the stomach area. Glutathione is another good example of liposomal goods. Glutathione is the main antioxidant of the human body, and the liposomal formula of this product quickly moves the substance where it is needed by avoiding the course of digestion.
What is a liposome?
Liposomes are small ball-shaped particles made of two molecules that form a thick layer of fat covering the water cabin. In other words, these are minimal, fat-soluble modes of transport for transporting nutrients to the cells of the body. The liposomal examination was published by Dr. Alec Banham of the Babraham Institute in Cambridge, UK.
Liposomal encapsulation technology
Liposomal encapsulation technology is a state-of-the-art distribution technique used by medical researchers to relocate medications that act by healing the body’s tissues. This distribution scheme method offers targeted transfer of dynamic composites to the body. It has existed since the early 1970s. Due to the extraordinary transferable competence of LET, several creators of moisturizers and beauty products (which are applied directly to a part of the body) have supported it. Due to the amazing results and benefits obtained from Liposomal Technology, many nutrition companies currently apply this method in the oral distribution of dietary supplements. The advantage is that it allows the nutrient to transport compact and non-decomposed natural compounds to certain tissues and structures. Ensuring that the limited doses are five to fifteen times less than the usual consumption of supplements, the distribution scheme’s efficiency has not changed.
This reduction is significant both therapeutically and in terms of cost reduction. It may not be appropriate to mention here that the normal transition of tablets and capsules and the localized deportation of substances that provide nutrition are affected by humidity, oxygen, and other inappropriate determinants. The substances may be classified according to the presence of enzymes (present in the esophagus’s oral and digestive fluids) that precede their assimilation into the body. Moreover, the materials used to hold things together, protective materials, gelatin, and sugars, are, in fact, preservatives that affect the assimilation procedure. This incomplete assimilation produced by inadequate fragmentation of tablets or capsules is a careful obstacle. However, LET frees the fortification of materials from worrying and aggressive consequences, which are expected to appear in the digestive tract. This is because Liposomal Encapsulation engages phospholipid liposomes to build protection that repels the negative effects of gastrointestinal fluids, alkaline solutions, salts, and free radicals of the body. The interval of this defense lasts from when the nutrients are directed to the digestive tract when the substances touch the tissue that receives them and when they are instantly drawn in by the cell arrangements and relocated to the intracellular zone.
The main part of the liposome in LET is made of phospholipids. All body cells are surrounded by a defense membrane that contains phospholipids. Phospholipids are needed by the body to develop and perform their functions. A crucial part of LET is PC liposomes, which function as regions to which condensed supplements are delivered. Liposomes are available in various dimensions, which are determined by how they are prepared. Their dimensions can range from micrometers to nanometers. Their assembly is such that they can have one plane, a binary plane, or several planes. A reduced liposome is more valuable for protecting shipments and passing through the human body than larger liposomes; the thinner the liposome, the longer its life and the greater its persistence. There are various techniques for formulating liposomes. The main method used to transmit food by mouth is an automated brand. The three main arrangements for assembling a mechanical planning procedure are:
All mixtures, including chemicals and liposomes, will eventually disintegrate through diet. The full status of liposomal expertise should use liposomes smaller than 200 nanometers with a structure consisting of two planes and Phosphatidylcholine. Eggs and soy are the most common resources and must be kept at room temperature, out of refrigeration. An outstanding illustration of LET’s subordination to life is vitamin C. Vitamin C is also referred to by some as a miraculous antioxidant because of its ability to dissolve and neutralize free radicals. In case a larger amount is needed, it is useful to inject vitamin C intravenously so that more of it is assimilated into the blood and tissues. When consumed orally, only 10 to 15 percent of vitamin C is used because its assimilation is suppressed in the gastrointestinal tract. LET technology has instantly improved and restructured the transfer of vitamin C into cells. So far, this is an unsurpassed way for vitamin C to gain access to the hepatic system in its healthy state. PC liposomes protect vitamin C from damage caused by enzymes and gastric fluid in the gastrointestinal system. As soon as they enter the body, PC liposomes move through the small intestine effortlessly and without stimulation. Liposomes transport the system to the liver in a comprehensive form and are equipped to empty their contents. PC liposomes in the liver are scattered. Polyunsaturated Phosphatidylcholine is swallowed by liver cells while releasing trapped vitamin C. When you use liposomal encapsulated vitamin C orally, the amount of vitamin C in the cell system increases without any indication of harmful effects such as abdominal pain, urine output, and any additional burden on the liver, which is to be commended.
Benefits of liposomal artemisinin
Technologically advanced liposomal preparations have suitable properties as drug transporters by intravenous and intramuscular methods. They are great in terms of element dimensions, distribution, encapsulation value, and other useful things. Their somatic and biochemical stability was also assessed. Moreover, in experimentation (using the whole living organism), the antimalarial effect of artemisinin-based liposomal preparations was substantiated in mice with Plasmodium bergei NK-65, a suitable prototype for malaria monitoring because this infection provides mechanical, functional, and cycle-like human diseases. Unaccompanied artemisinin, or the same fused with curcumin, was condensed into conservative PEGylated liposomes, and their overall effects (on living subjects) were evaluated as a contrast to unrestricted preparation. Mice were given artemisinin in an amount of 50 mg per kilogram of body weight per day, without supplements or only with curcumin as an additional drug, given in 100 mg per kilogram of body weight per day. Artemisinin began to reduce the levels of parasites that can be detected in the blood only a week after the treatment. It seemed to have an oscillating tendency in the blood concentration, which proved antimalarial efficacy.
In comparison, the use of conservative liposomes loaded with artemisinin (A-CL), conservative liposomes loaded artemisinin and curcumin (AC-CL), PEGylated liposomes loaded with artemisinin (A-PL), PEGylated liposomes loaded with artemisinin and curcumin (AC-PL) gave the impression of immediate results that opposed malaria. Both nano-condensed artemisinin and artemisinin mixed with curcumin cured mice (infected with malaria) within the equivalent post-injection time. All preparations showed a smaller amount of discrepancy in the plasma concentrations of artemisinin, which tells us that A-CL, AC-CL, A-PL, and AC-PL provided altered drug discharge and, as a result, there was a continuous result that counteracted malaria. In particular, A-PL has been shown to contribute to malaria’s most noticeable and satisfactory treatment effects in this mouse archetype. The improved endurance of A-PL in the blood imposes the use of these nanosystems as suitable inert-directed transporters for growing infections; this robust effect of the formulation is added to the mechanism of action of artemisinin, which acts in the erythrocyte cycle phase in humans as a blood schizonticide (an agent that selectively damages the sporozoan parasite cell). The predominant herbal treatment Artemisinin (also known as sweet wormwood), has been used by the Chinese population for many centuries. It has also gained recognition in the experimental control of drug-resistant falciparum malaria. Artemisia is a modest plant that grows in Southeast Asia and treats intestinal leeches. The World Health Organization has already declared it a harmless medicine against malaria.
In addition to the above, it has proven to be useful in the fight against malignancy. According to research studies, the realization with this plant relies on the fact that malignant cells and malaria parasites store iron, often collecting a thousand times more additional iron than normal cells would store. Artemisinin has two oxygen atoms that can separate in the presence of this amount of iron and consequently produce very sensitive free radicals that are introduced to destroy malaria parasites and many malignant cells. Treatment of individuals (suffering from malignancy) destroys these abnormal cells with artemisinin. However, normal cells remain unaltered. This remarkable ability to target malignant cells makes Artemisinin an exceptional trap driven by malignancy. Artemisinin represents (to those who suffer from some malignancy) the probability of using a non-lethal drug that is not only economical but also widely available. Artemisinin has an incredible safety contour, it should definitely be considered medicine when the usual treatments prove unsuccessful in providing results.
It should also be unquestionably used in people who suffer from malignancy but unwaveringly refuse to receive conventional treatments. Artemisinin is currently undergoing research and analysis to treat malignant cells, and certain Chinese researchers also present that artemisinin provided significant effects on hepatoma cells in humans. Artemisinin has also been shown to reduce the development of blood vessels and the manifestation of vascular endothelial growth factor in several tissues. Later, the pharmacological substance confirmed that a branch (derivative) of artemisinin, called dihydroartemisinin, has the ability to target human secondary malignancies located at a distance from the primary site of the melanoma.
The story of Donald, the mechanic:
Forty-seven-year-old mechanic Donald was quite healthy when he had to seek a herbalist’s advice when he freshly identified a horrible bulge (egg size). When the biopsy was performed, it turned out to be lymphoma. The herbalist immediately put him on therapy with a branch (derivative) of this Artemisinin plant and advised him to use it for two weeks. After two weeks, a slight reduction in the middle appeared on the bulge, but the border developed marginally. Disappointed that the bulge did not degenerate significantly, the mechanic decided to stop using this preparation. After one month, the herbalist received a mechanic call, who told him the good news that the tumor had disappeared completely.
The concept of liposomal vitamin C.
As we all know, Vitamin C (Ascorbic Acid) is one of the most recognized antioxidants worldwide. This essential food of health plays a decisive role in serving our body’s resistance system.
Liposomal vitamin C is a high-tech innovation in nutrient absorption and represents an incredible health compensation.
Liposomal vitamin C is packaged as a body cell to pass through the digestive barrier and deliver nutrients directly into the bloodstream. This has a much higher absorption rate, with about 90% of cells bathed in vitamin C. Some experts suggest that liposomal vitamin C is vastly superior to vitamin IV yield– an expensive but effective procedure performed quite often in hospitals and alternative health clinics. The dimensions of liposomes are important to a large extent when we talk about their ability to accept the highest vitamin C measures. The exact dimensions should be between 100 – 400 nanometers and must be verified by the FDA control authority to guarantee protection and value.
The best transporters for liposomal vitamin C are phosphatidylcholines, which help attach liposomes. The perfect amounts should be between 250-500mg PC for each dose in a liposomal vitamin C formulation. This phosphatidylcholine should be derived from non-genetically modified sunflower or soy lecithin.
Benefits of liposomal vitamin C.
Since vitamin C is essential for healthier eyes, many authorities accept that the intake of even 1,000 mg of liposomal vitamin C a day can stop cataracts.
Liposomal vitamin C has medicinal properties.
Use of liposomal vitamin C to treat pneumonia
Alan Smith, a New Zealand agricultural worker dedicated to the majority of processes and methods related to milk, butter, and cheese production, got swine flu when he was on vacation in Fiji. When he returned home, the flu quickly progressed to severe pneumonia, which caused him to lose consciousness and why he had to be placed in intensive care. A lung scan showed that his lungs were absolutely filled with fluid. Three weeks later, Alan’s doctor questioned his relatives about whether they were allowed to turn off the appliances and let him die. Alan’s son-in-law (with little information about medicine) convinced the doctors to try to inject a larger amount of vitamin C intravenously into Alan. Initially, doctors refused but had to give in after Alan’s three sons persuaded them to inject vitamin D into their father. As a result, they decided to give Vitamin C to Alan unsafely and with much doubt. So Alan received 25 grams of vitamin C intravenously in the evening and an additional 25 grams the next morning.
The next day, a CT scan of Alan’s lungs showed increased air movement, and after a few days, a radiograph showed air progress. A clear recovery was noticeable. On the other hand, doctors rejected the idea that vitamin C brought recovery, and as an alternative, they attributed the credit for the recovery to rotating the patient face down. Almost immediately after the IV injection of vitamin C, Alan was transferred from the breathing apparatus and started inhaling with his own lungs. Despite this, another consultant doctor suddenly sneezed, assumed that control of the case had been established, and discontinued vitamin IV C. Alan Smith’s condition quickly deteriorated to the point that his wife appealed for a consultation with this doctor who did not want to continue with vitamin C. But he had to give up when, once again, Alan’s sons insisted on vitamin IV. The doctor reluctantly continued to take vitamin C but only in small doses of one gram a day.
Alan began to recover and was finally relocated to a hospital that was closer to his home (although he was breathing with the help of a respirator). Alan’s relatives had to go through another conflict with another doctor, who again discontinued vitamin C therapy. This time the family reached for a legal representative who sent a warning letter to the hospital. The hospital was forced to continue with vitamin C, but again, in small amounts. As a final result, Alan could sit on the bed and be transferred to take fluids by mouth. However, based on their personal judgment, the relatives provided their father with 6 grams of vitamin C a day, which he took orally. This vitamin was in the form of an extremely easily digestible type known as Lipo-spherical vitamin C.
Alan endured until his recovery and was sent home from the hospital. At home, Alan’s neighbor John teased him that he owed him $ 15, which he paid for his suit’s dry cleaning, which he intended for Alan’s funeral.
Use of liposomal vitamin C to treat malignancy
Among malignancies, breast malignancy is the most common cause of death in women, accounting for about 1.5% of all deaths (Murthy and Aleyamma 2004).
Currently, there is progress in the health benefits of anti malignant mediators with a reduction in secondary adverse effects. The transportation of drugs to the end site fundamentally uses new expertise, e.g., Nanotechnology, in medicine. (Brigger et al., 2002). Consequently, it may be a solitary technique to consume a tumor-explicit effect with fewer side effects and less damage to biological cells. A wide range of nanotransporters for anti-cancer drug cargoes is used to combat drug resistance (Martin 2009), e.g., Drug-loaded liposomes (Sells et al., 1987; Cowens et al., 1993), polymeric nanosphere, polymeric nanocapsules (Couvreur 2001), compact nanolipides, and nanoparticles capable of magnetizing (Muller and Keck, 2004). For the aforementioned reasons, artemisinin was inserted into liposomes (A, form) and into the artemisinin slit in a pegylated liposome (B, form) to analyze their utility for breast cancer cell line, which is MCF-7. Effects of artemisinin liposomes (A) and artemisinin liposome polyethylene glycol 20000 (B) the breast cancer cell line (MCF-7) were considered. Zetasizer defined the thickness of the nanoparticles of both A and B. The Zetasizer Nano Z system is dedicated to quantifying zeta capacity and electrophoretic motion in aqueous and non-aqueous diffusions using Laser Doppler Micro-Electrophoresis (motion of distributed particles comparable to a liquid under the effect of a structurally unchanging electric field).
The involvement of nano transporters in drug distribution (e.g., nanoliposomes) plays a vital role in raising drugs’ beneficial manifestation.
(Int. J. LifeSc. Bt & Pharm. Crisp. 2013 Azim AkbarzadehISSN 2250-3137 www.ijlbpr.com
Vol. 2, no. 1, January 2013)