Garcinia Cambogia is a popular dietary supplement. HCA (Hydroxycitric Acid) Garcinia cambogia helps prevent obesity, lowers cholesterol and triglycerides, strengthens the immune system, and prevents ulcers.
In this article, you can learn all about this special herbal derivative similar to pumpkin and its effects, possible side effects and dosage.
- What is Garcinia Cambogia (HCA)?
- Main ingredient: HCA, ie. Hydroxycitric acid.
- How does HCA work?
- How to reduce appetite?
- Benefits of Garnicia Cambogia – HCA: What is HCA good for?
- Benefits of Garcinia Cambogia:
- The following is a summary of the benefits of Garcinia Cambogia:
- 1 – Effect of HCA – Weight loss
- 2 – Decreased appetite
- 3 – Low cholesterol
- 4 – Stabilized blood sugar level
- 5 – Fight against bacterial infections
- 6 – Cancer protection
- 7 – Protects the brain from injury and the digestive system from ulcers
What is Garcinia Cambogia (HCA)?
Garcinia Cambogia originates from a small pumpkin-shaped fruit (also known as garcinia gummi-gutta) that grows in Southeast Asia and India.
Garcinia is a large genus of the Clusiaceae family of plants that includes more than 300 species of trees and shrubs.
The bark of the plant is used for polishing gold and silver, its resin is used as a pigment for paintings and watercolors, while one part is used as a varnish.
The fruit of the plant is yellow or red, similar to a pumpkin. The fruit can be eaten, but it is not consumed because it has a very sour taste.
In Asia, the peel of the fruit is used to preserve food and improve the taste. It is traditionally used to treat constipation, rheumatism and menstrual pain.
Main ingredient: HCA, ie. Hydroxycitric acid.
The main ingredients of the fruit Garcinia Cambogia are Hydroxycitric Acid (HCA) which are responsible for the ability to reduce weight, appetite and fat accumulation in the body.
Both fruits and peels contain:
Xanthones (also found in the root)
Other parts of the plant also contain numerous alkaloids, flavonoids and phenolic compounds.
Garcinia Cambogia fruits contain a number of amino acids (e.g., arginine, asparagine, glutamine, threonine, glycine, proline, γ-aminobutyric acid, leucine, isoleucine, ornithine, and lysine). Extracts and compounds obtained from fruits reduce appetite and body weight.
How does HCA work?
Hydroxycitric acid can prevent the accumulation of fat in the body and reduce the level of fat in the blood:
Reducing the levels of enzymes for fat production (fatty acid synthesis) and blocking the enzyme (ATP citrate lyase) that promotes fat production (through acetyl coenzyme A).
It reduces the activity of proteins that increase the level of fat-producing enzymes (C / EBP-α, PPAR-γ, SREBP1c and aP2).
Increases the level of fat burning enzymes (lipoprotein lipase).
It reduces the production of triglycerides, phospholipids, cholesterol and fats (free fatty acids) in the liver.
How to reduce appetite?
By blocking ATP citrate lyase, in response, the body produces more glycogen in the liver, increasing the feeling of satiety.
The level of serotonin, a neurotransmitter that is responsible for suppressing appetite, increases.
Garcinia Cambogia adjusts immune function as follows:
Reduction of inflammatory cytokines (CPR, TNF-α, IL-1β)
Blocks and reduces levels of inflammatory enzymes [(myeloperoxidase (MPO), cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS), PGE2, 5-lipoxygenase)]
It acts as an antioxidant:
Increases the level of antioxidant enzymes (superoxide dismutase, glutathione reductase)
Reduces cell damage caused by oxidative stress
It reduces markers of oxidative stress in the brain, liver and kidneys (malondialdehyde (MDA), catalase, carbonyl protein (DNPH), catalase, nitration of tyrosine proteins and butyrylcholinesterases and increases nitric oxide levels in the brain).
HCA (hydroxycitric acid) can improve exercise performance by increasing fat breakdown and reducing carbohydrate breakdown. Glycogen retained for training is retained.
Benefits of Garnicia Cambogia – HCA: What is HCA good for?
Among the potential benefits of GC, weight loss is most often mentioned, which is attributed to the content of HCA (hydroxy citric acid) in it.
Nutraceuticals- in 2016. published a summary during the experimental tests. Garcinia has an anti-inflammatory effect, inhibits the development of ulcers, is a good antioxidant, has a hepatoprotective effect, cytotoxic and anti-diabetic properties.
Examination of different parts of the GC plant showed the presence of useful compounds such as xanthones, benzophenones, organic acids and amino acids.
Benefits of Garcinia Cambogia:
loss of appetite or decreased desire to eat as usual
the desire for unhealthy foods, such as sugar addiction, decreases
more positive mood (including happier, more energetic and less tired feeling)
increased energy and concentration
stabilizes blood sugar levels
better bowel emptying
reduced joint pain
stronger desire for physical activity
for the treatment of constipation, hemorrhoids and intestinal parasites
The following is a summary of the benefits of Garcinia Cambogia:
1 – Effect of HCA – Weight loss
Some studies have shown that Garcinia Cambogia can indeed help in weight loss as well as the above mentioned health problems.
Research suggests that HCA works by blocking an enzyme called adenosine triphosphate citrate lyase, which contributes to the formation of fat cells.
Studies comparing the effects of GC with controls have shown that it increases weight loss by an average of just one or two pounds but is a great support during your diet to achieve your ultimate goal.
Studies that have shown the effectiveness of HCA:
In a clinical study on 99 obese men, Garcinia cambogia and a weight loss drug (orlistat) reduced BMI, belly fat, subcutaneous fat and waist circumference within 3 months.
Two 12-week studies on more than 100 overweight and obese people in Garcinia cambogia reduced their weight by 3.6 kilograms.
After 16 weeks, HCA – Garcinia cambogia extract reduced fat, abdominal fat and subcutaneous fat in a clinical trial in 39 overweight individuals.
In two, eight-week studies in nearly 150 overweight and obese adults, hydroxycitric acid reduced body weight and BMI by 5–6%.
In an eight-week study in 40 obese adult subjects, Garcinia cambogia reduced abdominal and subcutaneous fat better than placebo.
Garcinia Cambogia extract reduced body weight by 4.67% in 30 overweight or obese adults (compared with only 0.63% in 28 placebo adults) in a 60-day study.
Hydroxycitric acid reduced body weight in a study in 21 obese adults after 2 weeks.
Garcinia Cambogia, HCA (Hydroxycitric Acid) with clinical trials has not always been successful in weight loss.
Although the results are different, the overall evidence suggests that Garcinia Cambogia may help with weight loss because it is used as a fat burning product.
2 – Decreased appetite
Studies also suggest that it is possible that HCA in Garcinia Cambogia may reduce appetite by increasing serotonin production in a neurotransmitter associated with calm and happy feelings and therefore sometimes by reducing appetite.
Animal experiments show that it can contribute to increased energy consumption.
GC does not affect all people in the same way. There are less risky ways to control appetite and increase serotonin production (e.g., eating a balanced diet with foods high in protein and healthy carbohydrates at regular intervals throughout the day).
3 – Low cholesterol
There are studies that support the claim that Garcinia Cambogia can improve cholesterol levels and lower high triglycerides. It can also help raise the levels of “good” HDL cholesterol.
It is not safe for those who are already taking medications that affect cholesterol.
There are many other natural ways to improve cholesterol levels, including consuming vegetables, nuts, seeds and beans from foods rich in fiber, and consuming more dietary fiber.
4 – Stabilized blood sugar level
There is evidence that Garcinia Cambogia can help regulate blood sugar levels by improving the intake of glucose (sugar) in cells for energy use.
One of the ways to improve weight loss is the inhibition of pancreatic alpha-amylase enzymes, changes in intestinal alpha-glucosidase and fatty acid synthesis. This can change the way carbohydrate is metabolized and help your body respond better to insulin.
If you have a history of fluctuating blood sugar levels, have pre-diabetic disease, have diabetes, or are taking medications that alter the effect of insulin, HCA can even lower blood sugar levels to a dangerous extent.
5 – Fight against bacterial infections
Garcinia Cambogia fruit extracts inhibit the growth of the following bacteria:
Escherichia coli (intestinal infections)
Klebsiella pneumoniae (pneumonia)
Pseudomonas aeruginosa (lung, urine and blood infections)
Bacillus subtilis (intestinal infections)
Staphylococcus aureus (skin infections, respiratory infections, food poisoning)
These are preliminary results that have not been fully confirmed in humans or even animals. Further research is needed to determine if Garcinia Cambogia can help with infections caused by these microorganisms.
6 – Cancer protection
Garcinia Cambogia contains good compounds like xanthones and garcinol that can protect against cancer.
They have been shown to kill cancer cells and prevent them from spreading. They also reduce inflammation in the brain, kidneys and intestines. It is well known that chronic inflammation in the body increases the risk of cancer.
Garcinol also has antioxidant properties, which means that it helps with a youthful appearance and can protect against chronic diseases.
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7 – Protects the brain from injury and the digestive system from ulcers
Garcinol has been found to protect the brain from injury by protecting special brain organs (called astrocytes) from the accumulation of neurotoxins.
It has also been found to protect the intestines from ulcers by protecting them from harmful radicals without hydroxyl.
HCA side effect?
Most studies have concluded that Garcinia Cambogia – HCA is safe for healthy people in the recommended doses, or even at a dose of 2800 mg of HCA per day.
If you have any illness or are taking any medication, talk to your doctor before taking this supplement.
HCA intake and administration
HCA is a popular and widespread dietary supplement and can be found in a variety of packages and dosages.
It is worth noting that the HCA content in Carnicia Cambogia is 50-60%.
Typical doses are usually between 50 and 1000 mg per day. The optimal dose of HCA is not yet known, which also means that a higher dose will lead to better results.
How long should you use HCA?
Since most research was based on a 12-week study, a few weeks break every 3 months is recommended.
When should you take HCA?
It is always best to follow the dosing instructions on the product label. Manufacturers generally recommend consuming 30 to 60 minutes before a meal.