How to prevent and treat osteoporosis with a healthy lifestyle

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Osteoporosis (porous bones) has taken on gigantic proportions among the population of industrialized countries. As the mineral composition of our bones is approximately 90% calcium salt, it is a widely held idea today that calcium deficiency causes osteoporosis, along with estrogen deficiency. However, although both factors play an important role in this process, there are many other factors.

In natural medicine, we place special emphasis on reading through bad life habits that contribute to an increased risk of osteoporosis, which we must avoid, both for the prevention and treatment of this disease. This information is of great interest if we consider that modern conventional treatment among many other harmful side effects includes the consumption of synthetic estrogens that can cause cancer.

In this first part, I generally deal with the story of bad life habits and other factors that cause osteoporosis. In the following parts of this text, I will deal with the description of useful foods and supplements for these patients, as well as the presentation of some therapies indicated in these cases.

What is osteoporosis?

Osteoporosis means “porous bones”.

It is a multifactorial disease, characterized by long-term loss of bone density, which increases the risk of fractures. It is a disease that generates pain, disability (due to fractures) and death associated with prolonged disability resulting fractures. Although it can affect all bones, damage the spine, hips and ribs.

Osteoporosis involves the complete deterioration of bones, that is, it includes a mineral structure and a part called the bone matrix (which consists of proteins and carbohydrates).

This fact allows us to confirm from the outset that the one-sided emphasis on calcium intake, which has marked medical campaigns against osteoporosis in recent decades, is misleading. In fact, a lack of calcium in the diet generates a disease called osteomalacia, but not osteoporosis.

It is only missing in osteomalacia calcium in bone, on the contrary, osteoporosis lacks various minerals, and the bone matrix also decays.

Unfortunately, modern medical campaigns have focused the public’s attention on calcium and hormones, forgetting the complexity of the problem. In fact, we can confirm that the set of mechanisms that regulate bone health and integrity is still not fully understood. However, various factors have been identified that promote this disease, but the general public has only received the insufficient and misleading idea that milk must be consumed in order to prevent osteoporosis.

Bone

bone osteoporosis

Bone is an active tissue, which is constantly being built (which is responsible for cells called osteoclasts) and reabsorbed or self-degrading (which is responsible for cells called osteoblasts).

During childhood and adolescence, we create bone faster than we destroy it, but between approximately 30 and 40, it reverses and we begin to lose more bone than we produce. Thus, building good bone mass in youth is essential to avoiding osteoporosis in old age.

The balance of bone metabolism is a complex process that includes hormonal, digestive, liver and kidney processes and a wide range of nutrients.

Furthermore, it must be emphasized that bone is not only composed of minerals (2/3) but also of the interstitial matrix (1/3), which consists of proteins and carbohydrates. The regulation and intervention of all these factors are only partially understood.

Types of osteoporosis

1) Menopause: associated with hormonal changes, women from 50 to 75 years.

2) Senile: persons older than 70 years (affects twice as many women as men).

3) Secondary: caused by drugs or health problems.

4) Juvenile idiopathic: in children, adolescents and young people, without obvious cause.

Diagnosis of osteoporosis

The most common method is to measure bone density with X-rays.

Two parameters are used in this exam:

T-index (T.score): compares the bone mineral density of a patient with that of a healthy white woman from 25 to 30 years of the same sex as the patient.

Z-score (Z-score): compares the patient’s bone density with the bone density of a person of the same sex, age and ethnic group as the patient.

Values established by the WHO

Greater than -1 T. Normal

Between -1 and -2.5 T. Osteopenia

Less than -2.5 Osteoporosis

Less than -2.5 and suffered one or more fractures of fragility Established osteoporosis.

Incidence of osteoporosis

Osteoporosis has become a pandemic within industrialized countries, and medium- and long-term projections indicate a steady increase in the disease.

For example, in the United States, about 44 million people have osteopenia (a decrease in bone density that can lead to osteoporosis), and 20 million have osteoporosis.

Worldwide, more than 200 million people suffer from osteoporosis and its incidence is increasing.

In the United States, 15 million fractures occur annually due to osteoporosis, and $ 27 billion is spent on their medical care.

In that country, more women die from osteoporosis than from breast and uterine cancer (combined).

Worldwide, osteoporosis affects 1 in 3 women over the age of 50 and 1 in 8 men of the same age range.

Osteoporosis-related fractures occur every 30 seconds in the United States, and hip-related fractures occur every 30 seconds in the European Union.

2007. 200 million women worldwide are diagnosed with osteoporosis. These figures affect the following depending on age:

– 1 in 10 women aged 60 years.

– 2 out of 10 women in their 70s.

– 4 out of 10 women in their 80s.

– and 6 out of 10 women in the 1990s.

In 2006. years, worldwide, there was a general osteoporotic fracture every 3 seconds, and a vertebral fracture every 22 seconds. Until 2050. It is estimated that hip fractures in men will increase by 310%, and in women by 240%.

PICTURE OF DISEASE IN MEXICO

In 2009 At the age of 17, 17% of women and 9% of men over the age of 50 were diagnosed with osteoporosis.

Hip fracture is on the rise:

– 1.2 million in the 90s.

– 2.6 million estimated for 2025. year.

– And 110,055 cases by 2050. year, an increase of 431%.

Annual data in the United States

Osteoporotic fractures 1500000

Heart attack 500,000

Emboli 225000

Breast cancer 184000

Cancer of the uterus, ovaries and cervix 76000

Before we move on, a brief comment on this global panorama of osteoporosis is necessary. As the reader sees, the numbers are staggering. The question of the causes of such a disease immediately arises. Modern medicine presents it to us as something simultaneous with the human aging process: hormonal and metabolic changes, and offers us, basically, hormones and calcium for its treatment, plus another series of drugs.

Nevertheless, the evidence speaks against this perspective:

Why does osteoporosis increase and turn into an epidemic? Why does this particularly affect the population of industrialized nations?

If the solution is calcium intake, how to explain that countries with the highest calcium intake, such as the United States, have very high incidence rates of osteoporosis, as opposed to countries and / or populations that have lower calcium intake? ?

It is clear that we need to look at the matter more closely. Fortunately, as we will see, we can do a lot to effectively prevent and treat this disease.

Who is at risk for osteoporosis?

There are several invariable risk factors that affect its frequency:

Age : As we age, we lose bone mass. This begins in the third decade of life: we usually lose between 0.5 and 1% of bone mass per year. Bone loss occurs slowly but continuously, and various factors can lead to osteoporosis. As we age, the absorption of minerals and nutrients critical to the bones in the intestines decreases, and our metabolism functions less and less efficiently.

Gender: Osteoporosis primarily affects postmenopausal women. For example, in the United States, 80% of cases are women. In the early years of menopause, a woman can experience a rapid increase in bone loss (going from 1% annual loss to 7%), but up to 75. years, the risk of osteoporosis is almost the same for both sexes.

Race: White women and Asians have the highest risk of osteoporosis, and black women the lowest.

In the United States, Asian women over the age of 65 have twice the fracture rate of African-American women.

Causes of osteoporosis.

Family background

Having close relatives with osteoporosis significantly increases the risk of the disease, it is estimated that this increase can be from 60% to 80% if they have a first-degree relative who has suffered from osteoporosis.

The effect of weight

Being overly lean, ie having a very low level of body fat, inhibits the synthesis of progesterone and estrogen and contributes to an increased risk of osteoporosis.

Causes associated with modern life

So far, a scenario has been established according to which osteoporosis could be considered a pandemic inherent in the prolongation of the average life expectancy in modern society, so it seems to us to be something related to the aging process.

But while it is obvious that osteoporosis is a disease typical of the third stage of life and in which female hormonal changes play an important role, it is necessary to point out that in the modern lifestyle there are various factors that may explain the prevalence of this disease today.

As we will see, there are several factors – in addition to hormonal and age that contribute to osteoporosis, such as tobacco, coffee, alcohol, sugar, excess protein and sodium, etc. But the most important factor of all is physical activity. Exercise is the main factor that determines bone density.

Some studies have noticed that one hour of moderate exercise, three times a week, is enough to prevent bone loss and even help increase it in postmenopausal women.

In contrast, going to the opposite extreme, immobilization doubles the excretion of calcium in urine and feces, generating a serious problem of imbalance in the metabolism of the said mineral.

Even the use of plaster or immobilizers to treat fractures generates bone demineralization.

It is important to note that the type of exercise performed to strengthen the bones should carry body weight (so, for example, swimming has no pronounced effect) and to avoid exercises with a big blow.

Lifting weights can be very helpful, but of course adhering to a moderate routine, which avoids the risk of fractures or injuries due to carrying excessive weights.

Smoking

Smoking has several negative effects on bone health.

It inactivates the effect of estrogen on osteoclasts, (bone cells responsible for bone resorption. Estrogen normally slows down the process of bone resorption (destruction). In addition, smoking reduces the level of estrogen in the blood.

On the other hand, smoking reduces the excretion of carbon dioxide from the lungs and generates its retention, thus increasing the level of carbonic acid in the blood. The body counteracts this acidity by extracting minerals from the bones, which are then excreted through the urinary tract. Smokers are usually less physically active.

Because of all this, women who smoke generally suffer from osteoporosis earlier than those who do not smoke.

Tobacco is a major source of cadmium pollution, a heavy metal that can affect bones.

In fact, quitting smoking is an essential part of the natural treatment of osteopenia and osteoporosis and is essential for anyone who wants to have a healthy bone mass.

Alcohol

Consumption of more than three drinks a day has a negative effect on bones:

Chronic consumption of alcoholic beverages can cause hyperparathyroidism, which in turn accelerates the excretion of calcium from the bones into the blood.

Alcohol inhibits the production of enzymes in the kidneys and liver that act in the metabolism of vitamin D (see below).

Alcohol reduces the action of hormones, especially affecting testosterone, which inhibits the activity of bone production (osteoclasts).

Excessive alcohol increases the production of cortisol, which in turn causes a decrease in bone production and increases bone destruction.

Alcoholism is accompanied by poor nutrition, creates toxic effects on osteoblasts that produce bones, and at the same time accelerates the action of osteoclasts, which are responsible for destroying bones.

Alcohol thus creates a profound imbalance of bone metabolism. By stopping alcohol consumption, osteoblast activity recovers.

Caffeine and stress.

Caffeine has a diuretic effect and increases the excretion of calcium in the urine, caffeine acts for 3 hours, not all day.

This effect of caffeine can be mild if:

  • do not consume more than 400 mg per day
  • if the diet provides enough calcium (600 mg or more per day)
  • A cup of coffee provides approximately 150 mg of caffeine, and a 300 ml Coca-Cola provides 45 mg.

On the other hand, let’s say caffeine stimulates the adrenal glands and contributes to stress. We have already talked about how increasing the production of the hormone cortisol, whose production increases with stress, affects bone metabolism.

Refined sugar

There is a direct correlation between the amount of daily consumption of refined sugar and the level of urinary calcium excretion.

Carbonated drinks

When the level of phosphate rises in the blood and the level of calcium decreases in correlation, the body extracts calcium from the bones to balance the balance of phosphate and calcium, and then the kidneys excrete excess calcium from the blood in the urine.

Non-alcoholic beverages that contain large amounts of phosphate (such as cola) contribute to the imbalance of calcium levels. Large amounts of phosphate are added to these soft drinks to dissolve the excess sugars they contain and improve the taste.

The contribution of soft drink hyperconsumption in Mexico to the osteoporosis pandemic will certainly be pronounced in the coming decades. This is due to the fact that more and more children and young people consume large amounts of soft drinks, which can affect the formation of their bone mass during the first 25 years of life, which is one of the decisive factors, if not the most important, risk of osteoporosis.

MEXICO IS THE WORLD CHAMPION IN THE CONSUMPTION OF SOFT DRINKS, ACCORDING TO THE NATIONAL HEALTH AND NUTRITION SURVEY IN 2012 THE YEAR ACCORDING TO THE CONSUMPTION OF CAPITAL PER CAPITA PER PERSON IS 173 LITERS. IF WE CALCULATE A POPULATION OF 110 MILLION, THIS MEANS ANNUAL CONSUMPTION OF 19 BILLION LITERS A YEAR.

High consumption of animal proteins

An association between high animal protein consumption and the incidence of osteoporosis has been observed.

Since the late 1960s, some researchers have pointed out that the body dissolves bones to release minerals into the bloodstream to counteract excessive acidity.

Animal proteins (eggs, dairy products, meat) generate the balance of acids in our body when they are metabolized, on the contrary, fruits and vegetables make us alkaline and fight acidity.

In a large study, a group of researchers compared data from 34 studies conducted in 16 different countries to determine if there was a correlation between hip fracture incidence and animal protein consumption levels, the researchers found a strong correlation between animal protein consumption and hip fracture incidence. , which had no explanation regarding the level of calcium or calorie intake in the diet.

This was confirmed by studies in the Eskimos, one of the nations with the highest protein intake (and the lowest fruit and vegetable intake).

Eskimos consume more than 200 gr. daily protein, Americans about 75 gr. daily, for comparison. this is the probable cause that Eskimos have higher bone loss even at earlier ages than the United States (which has the highest risk of osteoporosis in that country).

However, let us mention that there are at least two other studies that did not find a difference in bone mass or bone metabolism, when comparing women before and after menopause who had a vegetarian diet.

In any case, more studies are needed for confirmation.

However, the two factors that characterize a vegetarian diet, less meat, more fruits and vegetables, naturally have their impact on the prevention of osteoporosis.

It is now necessary at this point to present the works of Evolutionary Medicine, which led to the justification of the Paleolithic diet, which existed for about 2.5 million years. The Paleolithic diet, although it had ecological and cultural variations, presented some contrasting parameters with the diet typical of civilization and even more with the diet typical of the industrial age: dairy products were not consumed, cereals were not consumed. The diet consisted of food of animal origin and a large amount of wild plants. Then we can confirm that it is not only the consumption of significant amounts of animal protein that creates the acid / base imbalance that slowly but systematically demineralizes us, but the high consumption of animal protein accompanied by low consumption of vegetables. Which gives us a basis for the next section.

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Consumption of fruits and vegetables

The modern diet is typically associated with a progressive reduction in fruit and vegetable consumption.

There are some studies that have shown the importance of maintaining a high consumption of fruits and vegetables for bone health.

In a study conducted among the surviving participants of the famous heart health study, known as the Framinghan heart study, the correlation between diet type, supplement consumption and bone mass density, measured in the hip, was the benchmark of this group of elderly people.

Consumption of fruits and vegetables was associated with both men and women with higher bone density.

In addition, the decline in bone mass in the following years was smaller in those who consumed this food the most.

A direct correlation was also observed between magnesium and potassium intake and bone density.

Another study examined the past eating habits of premenopausal women and noted that there was a correlation between the history of high consumption of fruits and vegetables and higher bone density of the spine and trochanter.

A possible explanation for these effects lies in the contribution of magnesium and potassium obtained from food. Both minerals have an alkalizing effect, thus reducing bone loss and excretion of calcium through urine. In fact, fruits and vegetables are known to produce an alkaline (antacid) balance in the body, while meat, cheese and fish contribute to the acidity of the body.

Modern diet with high consumption of proteins and animal fats, high consumption of refined and unwanted carbohydrates (also acidifiers) and low consumption of fruits and vegetables, generates progressive acidification of the body, forcing the body to extract minerals from bones to balance PH, with consequent increased excretion minerals through the urinary tract.

We must emphasize that fruits and vegetables also provide a whole range of minerals and trace elements that are necessary for our bones.

Abscess and its treatment – diet, aromatherapy, herbs

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An abscess, what does it represent

An abscess is a purulent inflammation of the tissue with the formation of a purulent cavity. It can occur in muscles, bones, subcutaneous tissue, in organs and between them. Abscesses can develop on their own or as a complication of other diseases (trauma, pneumonia, angina).

If a large amount of pus accumulates, the abscess may rupture, leading to pus coming out. This causes an inflammatory process, which can cause blood vessel sepsis and other, no less dangerous consequences.

Therefore, it is necessary to know how to treat an abscess at an early stage.

Accumulation of pus in the tissue bag occurs as a result of decomposed bacteria that the body destroys.

They form pus white blood cells fighting infection.

Abscess: causes and factors of development

Like any other purulent disease, an abscess develops due to a violation of the integrity of the skin and the penetration of pathogenic purulent bacteria into the body. In the reproduction of bacteria on the skin, pus appears and bumps form that fill with pus. It should be noted that some bacteria are capable of causing abscesses as part of the normal microflora of our organism. However, under certain conditions, these bacteria begin to multiply uncontrollably, creating purulent masses. A large number of these microorganisms inhabit the mucous membrane of the mouth, nasal cavity, genitals, mucous membranes of the eye, small and large intestines.

It should be noted that it is quite difficult to detect the pathogen of an abscess, and the effectiveness of treatment depends on the exact identification of the microorganism. There are a large number of pathogenic bacteria that can cause soft tissue abscesses.

The most common causes of abscesses are:

Staphylococci

In most cases, skin abscesses are caused by staphylococci. According to recent medical studies, staphylococcus is found in 28% of cases of skin abscesses. About 47% of cases of abscesses that develop in the upper half of the body (abscesses of the neck, face, chest and armpits) are caused by staphylococci.

E. coli

One of the most common microorganisms that inhabit the large intestine and is excreted by microscopic examination of feces. This microorganism is often the cause of the development of abscesses in the lower half of the body.

Types of abscesses

Abscess – limited purulent inflammation of adipose tissue, accumulation of pus in the cavity.

Abscess in the Douglas space Douglas space is limited by the pelvic peritoneum, located in men between the rectum and the bladder, in women – between the wall of the uterus and the rectum. Abscesses in it most often occur due to the outflow of purulent-inflammatory exudate with diffuse peritonitis of various etiologies, with the pelvic location of the appendix.

Subphrenic abscess – accumulation of pus under the diaphragm. It is most often formed on the right side with peritonitis under the influence of the suction effect that occurs between the dome of the liver and the diaphragm.

Pulmonary abscess

Brain abscess

Medications

Some medications can cause sterile abscesses on the skin that look like cellulite.

In some cases, some diseases (eg pharyngitis, paraphyproctitis, nail ingrown, Crohn’s disease, osteomyelitis, etc.) can be complicated by the appearance of abscesses.

Symptoms and diagnosis of abscess

For superficial abscesses, the manifestations of acute inflammation are typical: redness of the skin, local pain, local fever, swelling, organ dysfunction. The general symptoms of abscesses are typical for inflammatory processes wherever they are: headache, malaise, fever, loss of appetite, weakness.

Herbal abscess treatment

Decoction of echinacea helps the body against bacterial infections: two teaspoons of the root are poured into a glass of water, after boiling it is boiled for 10 minutes. It is drunk 3 times a day.

Nutrition

Frequent ulcers with abscesses can be caused by a lazy stomach and untimely emptying. The following tips help flush out toxins and improve digestion:

• Limit the use of fatty foods, including meat, eggs and dairy products.

• Limit the use of sweets and carbohydrates (white flour and sugar).

• Increase the use of fresh fruits and vegetables.

It is recommended to take:

• Zinc: 45 mg. daily.

• Vitamin A: 50,000 iU daily for two weeks.

Aromatherapy for abscesses

Tea tree oil has an antiseptic effect. Prepare a solution of 2 drops in a cup of tea and smear the abscess with this solution several times a day.

Homeopathy for abscess

When the abscess is very mature and causes stabbing pain: sulfur (Hepar sulfphuris).

At the very beginning, when the abscess pulsates and becomes red and inflamed: Belladonna.

Take 1 tablet per hour to 4 doses and repeat if necessary

Chinese remedy for abscess

Abscesses are thought to be caused by excess body heat. Plants that lower the temperature are recommended: Chinese golden thread, abscesses of wild chrysanthemums and violets. They are prepared as tea.

Maslačak čaj od maslačka lišće maslačka – Dokazana lekovita svojstva kroz primere

Hydrotherapy for abscesses

Prepare a hot compress by dipping pure raw cotton in hot water. Keep it on the abscess to remove the pus.

Traditional medicine for apseces

Your doctor may remove pus from the abscess. recommend an antibiotic to prevent possible infection.

Preparations that help with abscesses

Hair loss: stop using “effective preparations”!

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Which hair loss medications can be used depends on the type of hair loss and its causes. We present the concept against hair loss.

There are many remedies for hair loss. Few of them can be called “natural”. Also, very few of these drugs treat the real causes of hair loss. Natural remedies are different. They solve the problem at the root – in the true sense of the word.

But let’s start with the different types of hair loss. Because each type of hair loss has its specific causes, so each type of hair loss should be treated and taken seriously.

These are the types of hair loss

Hair loss is roughly divided into four different types of hair loss, with the fifth “type” being a special case:

  • Hereditary hair loss (also known as androgenic or hereditary hair loss)
  • Circular hair loss (Alopecia areata)
  • Diffuse hair loss
  • Hair loss with scars
  • Special case: hair loss during chemotherapy

Hereditary or androgenic hair loss

Hereditary or androgenic hair loss can affect women and men alike, and the vast majority of men are affected. This form of hair loss is called hereditary, because hereditary hypersensitivity of certain hair follicles to the hormone DHT.

DHT stands for 5-alpha dihydrotestosterone. It belongs to androgens, which belong to sex hormones. Androgens are responsible for male characteristics such as strong muscle development, beard growth, body hair and a deep voice.

DHT is made from testosterone by a specific enzyme (5-alpha reductase), and DHT is more active than two male hormones.

Androgenic hair loss in women

If women of reproductive age are affected by androgenic hair loss, the hair thins. Women also have elevated levels of testosterone or dihydrotestosterone, with PCOS, polycystic ovary syndrome, very often involved. It is the most common hormonal disorder in women of reproductive age.

Androgenic hair loss in men

In men, androgenic hair loss is not so easily influenced by natural measures. However, there are herbal remedies that can be used to gently affect the hormonal balance.

It is also now assumed that diet and lifestyle affect gene expression, so that a person is not always at the mercy of his genes for better or worse.

Therefore, a holistic approach is also very beneficial for androgenic hair loss, which – even if it could not reverse hair loss – can often lead to slowing down and moreover not only have a positive effect on hair and scalp health, but in any case general health. significantly improves mental performance and physical fitness.

Circular hair loss

Circular hair loss (alopecia ariata) occurs in rounded, completely bald areas on the head. In extreme cases, however, all the hair and hair can fall out, even the rest of the body.

Circular hair loss is currently considered an autoimmune disease, which means that the body’s own defense cells (so-called cytotoxic T cells) attack the hair follicle cells in places, believing that these are foreign structures that need to be fought. . Studies have found infiltration of cytotoxic T cells in the affected areas of the scalp.

Other autoimmune diseases are often present in circular hair loss. If so, the prognosis seems less good. After a few years, nail changes can occur in over 60 percent of patients (longitudinal grooves, fragility, rough surface, etc.).

Up to 50 percent of sufferers fully recover from circular hair loss during the year. At up to 25 percent, however, it increases to the point of complete loss of all hair on the head or even the entire body.

Diffuse hair loss

With diffuse hair loss, the hair becomes lighter. So there are no single bald spots. In most cases, women are affected.

Diffuse hair loss is usually of the late type, which means that the harmful effect interrupts the hair growth phase (see the next section “Three phases of the hair life cycle”) and the hair goes into a resting phase. It lasts up to 4 or even up to 6 months. Only then does the hair fall out, so in the case of diffuse hair loss, you should always think about what happened a few weeks or months ago, which could be a harmful factor, so that you can then take appropriate measures.

Possible harmful factors include:

childbirth,

Infections,

high temperature,

Hemorrhage (excessive blood loss),

Diseases of internal organs (e.g. Liver, thyroid (usually insufficiently active thyroid) and other endocrine organs,

Severe diseases (cancer, tuberculosis, etc.),

strict diets or periods of starvation or generally chronic deficiencies of nutrients or vital substances (e.g. iron deficiency due to abundant

menstruation, zinc deficiency, vitamin D deficiency, etc.)

accident or operative trauma,

severe emotional stress and some medications (e.g., beta blockers, statins, thyroid medications, or blood thinners).

The following possible causes can be added:

Improper hair care or coloring with chemical hair dyes as well as one

Pollution (eg heavy metals)

Allergies

Menopause

Chronic acidosis

Hair loss with scars

Hair loss with scars appears on bald spots that eventually become scars. This hair loss is often associated with irreversible damage to the hair follicles. Hair no longer grows in the relevant areas. Because strong inflammatory processes are present during this form of hair loss, conventional medicine treats corticoids (cortisone) to prevent inflammation and stop hair loss.

However, inflammation of hair loss with scars does not occur without other factors. Hair loss is associated with certain diseases, such as lupus erythematosus ,, psoriasis ,, Fungal Infections or certain tumors. Since these diseases are the real cause of hair loss, the focus of therapy should not be on hair loss, but on the disease that triggers it.

Special case: hair loss during chemotherapy

Chemotherapy damages all hair that is in the growth phase (see the next section for the three phases of the hair life cycle). The damage is so great that these hairs do not go into the resting phase, but break at the root immediately or within a few weeks. There is talk of hair loss (effluvium) of the early type.

For now, only those hairs remain that were already dormant during chemotherapy (ie, a maximum of 20 percent of the total hair), but which also fall out 87ztrde4w no later than 2 to 4 months.

Because hair follicle cells belong to those cells that divide very quickly, the follicles recover quickly, so that the first new hairs can be seen again only 4 weeks after the end of chemotherapy. Sometimes it takes a little longer (6 to 8 weeks).

Hair loss cannot be prevented here, but you can speed up and support the regeneration of the body with measures for detoxification and strengthening after chemotherapy (after consulting a doctor).

Three phases of the hair life cycle

Hair is subject to a certain developmental cycle. Three phases can be distinguished here. If you know this, you will better understand why hair does not always fall out immediately after the harmful effect, but maybe only after a few weeks.

Anagen = growth phase: 2 to 10 (usually 3 to 6) years, hair grows. The longer the anagen, the longer the hair becomes. Anyone who has hair that does not grow for a particularly long time has a shorter phase of anagen. In healthy people, 80 percent of hair is in anagen. If it is a harmful effect, then the hair turns into catagen, and then into telogen, so that weeks or months can pass after the harmful effect until hair loss is shown.

Catagen = transition phase: 2 weeks, during which time the hair follicles stop their metabolic activity, the hair is no longer delivered and also no longer grows.

Telogen = resting phase: 2 to 4 months, at the end of the telogen phase hair falls out. In this condition, it should be less than 20 percent of the hair.

Can Pfeiffer’s glandular fever cause or trigger hair loss?

Epstein-Barr virus (EBV) is currently thought to be responsible for Pfeiffer’s glandular fever, especially autoimmune diseases, which is why researchers at the University of Texas / Houston investigated a possible link to circular hair loss back in 2008.

Of the 1586 patients with circular hair loss who felt that external factors caused their hair loss, 12 people had EBV infection in the six months before hair loss, which is less than 1 percent, but still shows that EBV infection can be risk factor.

Causes that may be responsible for hair loss

Earlier in the introduction of different types of hair loss, we have already listed some of the causes. However, from a naturopathic point of view, we will also ask the question:

Why does androgenic hair loss lead to hair follicle hypersensitivity to DHT and why do women develop a hormonal disorder (PCOS)? People will ask themselves, how is it that an autoimmune disease develops and the body turns against itself? Why does the thyroid gland no longer work properly, so that an inactive thyroid gland is diagnosed?

In all these cases, there is an imbalance in the body. Certain influences prevent healthy reactions of the organism, lead to irritation, malfunctions, in the intestines, IBS, which could accelerate the development of autoimmune diseases. These negative impacts include:

  • poor nutrition (which nourishes the body and at the same time does not provide enough vitamins, minerals, antioxidants and nutrients)
  • overloaded liver
  • intestinal flora disorder or poor intestinal health
  • lack of stress management
  • too many stimulants (alcohol, cigarettes, sugar, caffeine)
  • too little sleep, too little fresh air, and too little exercise
  • unnatural hair and body care

All of these factors cause disorders in the system (in the immune system, in the hormonal system, etc.) and can eventually lead to hair loss. So, what to do in case of hair loss from a holistic point of view?

These drugs are used for hair loss

In naturopathy, individual drugs against this or that are rarely used. On the other hand, a holistic attitude is approached and the above problematic habits are corrected.

Even holistic concepts for autoimmune diseases (including circular hair loss or causative diseases due to hair loss scars) now consist of the same measures listed below that have been recommended in naturopathy for decades for diseases of all kinds (see “Treating Autoimmune Diseases Successfully” by Dr. Susan Blum):

Healthy diet

Strengthen the liver

Intestinal health rehabilitation

Proper stress management

Optimization of individual supply of vital substances (acidification, mineralization and elimination of vitamin deficiency)

Detox the body if needed

Quality sleep, fresh air and lots of exercise

Natural body and hair care products

Targeted dietary supplements adapted to the individual situation

If there is diffuse hair loss, most of the possible causes of diffuse hair loss can also be automatically eliminated by this concept.

Naturopathic anti-hair loss medications do not only treat the scalp, hormonal system or immune system. Instead, they provide the body with everything it needs to find a healthy and harmonious balance, and hair loss can often be stopped and new hair growth can begin.

In addition, of course, means can be used that have a specific effect on harmonizing and strengthening the health of the scalp and thus prevent hair loss directly on the spot and ensure new hair growth, e.g. B. natural hair lotions, hair tonics, hair conditioners, etc.

However, these drugs should be seen only as additional measures, because the real correction of hair loss always comes from within, ie. when the organism regains strength and can solve the problem independently thanks to its re-self-regulation.

Only in the case of genetic hair loss, individual drugs are needed that specifically affect the hormonal system and thus reduce the harmful effects of high levels of DHT on hair follicles:

In case you want the help of a professional in treating the problem of hair loss, contact us

    Three drugs for androgenic / genetic hair loss

    According to initial studies, the following three natural substances can lower DHT levels, ie. Prevent the conversion of testosterone to DHT. These three drugs include:

    • Sulforaphane – a secondary herbal substance that is especially found in broccoli and broccoli sprouts and is known for its strong antioxidant effects in the fight against cancer and anti-inflammatory effects.
    • Pumpkin seed oil
    • Palmetto saw extract

    Sulforaphane for genetic hair loss

    We wrote a lot about sulforaphane – it works as a substance against cancer and arthritis, on how it gives hope to people with autism, it helps with respiratory diseases.

    Sulforaphane is one of the so-called isothiocyanates, which are sometimes called mustard oil glycosides. Sulforaphane is found in especially large quantities in broccoli, but – in smaller quantities – in all other cabbage vegetables such as cauliflower and kohlrabi, horseradish, rocket, cress, radish and many other vegetables from the cruciferous family.

    Sulforaphane has been studied in a Japanese study because of its effects on genetic hair loss. Researchers in March 2016. wrote that sulforaphane apparently managed to reduce DHT levels.

    According to the researchers, sulforaphane increases the expression of the enzyme that breaks down DHT. It is the enzyme 3-alpha-hydroxysteroid dehydrogenase (3a-HSD).

    Researchers have not yet given specific dosage recommendations to combat hair loss for use in humans. However, the University Hospital in Heidelberg recommends 0.36 mg of sulforaphane per kilogram of body weight for cancer therapy, which can be a guide for dosing and use.

    If you take sulforaphane as a dietary supplement, then a daily meal – depending on the product – provides 50 to 100 mg of sulforaphane.

    One broccoli (500 g) contains about 50 mg of sulforaphane – always depending on the season, variety and freshness. Broccoli sprouts provide up to 100 times more sulforaphane, so a tablespoon of sprouts can contain as much sulforaphane as a head of broccoli.

    So, if you eat a lot of broccoli or vegetables mentioned above, as well as broccoli sprouts, in addition to dietary supplements, you could achieve an effective dose very quickly.

    Pumpkin seed oil for genetic hair loss

    Another natural remedy for genetic hair loss may be pumpkin oil. The oil inhibited the enzyme 5-alpha reductase in a randomized placebo-controlled study from 2014. years. This enzyme enables the conversion of testosterone to DHT. If inhibited, DHT levels do not rise as much.

    In a Korean study, 76 men with genetic hair loss received 400 mg of pumpkin oil or placebo daily for six months. At the end of the study, it was determined that the pumpkin seed oil group had fuller hair than the placebo group. Hair increased by 40 percent. No side effects were found.

    In case of genetic hair loss, you can take a spoonful of pumpkin oil every day or simply prepare a daily salad with pumpkin oil dressing.

    Palmetto saw for genetic hair loss

    Preparations made from the fruits of the saw palmetto (palmetto saw extract) are known for their positive effect on benign prostate enlargement (benign prostatic hyperplasia / BPH). Already in 1996. In the review, it was found that palmette extract (160 mg twice daily for 1 to 3 months) can achieve equally good results in BPH as finasteride 5 mg.

    Although the specific cause of BPH is still unknown, DHT is believed to be involved. On the one hand, there may be high levels of DHT, on the other hand, it is suspected that the cause is the dominance of estrogen (the level of estrogen increases in relation to the level of testosterone).

    Palmetto saw extract now seems to be able to reduce DHT levels. This increases testosterone levels – an effect that is especially evident when palmetto saw extract is combined with astaxanthin, as we have described here: treating testosterone deficiency

    A drop in DHT levels would also be helpful in the case of genetically induced hair loss. The less DHT in the blood, the less DHT around the hair roots and the less hair will fall out.

    Therefore, in 2012. the researchers examined the effects of saw palmetto extract on genetically induced hair loss (compared to the effects of finasteride) in the study. They reported their new findings in the International Journal of Immunopathology and Pharmacology:

    The study involved 100 male patients diagnosed with genetic hair loss. One group took 320 mg of palmette extract daily for six months, while the other took 1 mg of finasteride daily.

    Although finasteride as a whole was more successful, many men (38 percent) who took sawdust palmetto extract also showed higher hair growth. Palmetto saw extract was especially effective in the crown area, ie. Less in the area of the front head.

    How to combine three drugs against genetic hair loss

    If you prefer to try natural remedies for genetic hair loss, you can very well combine the three described measures:

    Palmetto saw extract and sulforaphane are taken as dietary supplements. We recommend this palmetto saw extract in high doses against hair loss  i  100 mg sulforaphane daily.

    In addition, broccoli, broccoli sprouts and pumpkin seed oil (and pumpkin seeds as well) are often included in the menu. We recommend that you grow broccoli sprouts yourself.

    How can probiotics help against hair loss?

    Poor intestinal health and diseased intestinal flora (dysbiosis) are now considered the main causes of many chronic diseases. Therefore, probiotics are often recommended to regulate the intestinal flora. These are preparations with beneficial intestinal bacteria that renew the intestinal mucosa, have anti-inflammatory and detoxifying effects, expel harmful bacteria, have a positive effect on the immune system and can even alleviate stress reactions.

    It is these properties that are needed for hair loss. Since hair loss is often associated with inflammatory processes in hair follicles, it can also be associated with stress  and in the case of circular hair loss, it may actually be the result of dysbiosis. Therefore, it is suspected that taking probiotics can help with hair loss, as several studies with mice have already shown. Animals receiving probiotics always had good hair growth and shiny hair, which was not the case in the control groups.

    In the study at Massachusetts Institute of Technology probiotics were found to lead to an enormous increase in active hair follicles in mice. Thus, there was much more hair in the active growth anagen phase than in animals that were not given probiotics. Overall, it could even be observed that the probiotic mice as a whole were in a condition that is usually typical of much younger mice. Probiotic bacteria also had a rejuvenating effect on animals.

    In traditional Chinese medicine, hair loss and unhealthy-looking hair are also signs of indigestion. Because in the case of digestive disorders, nutrients are no longer absorbed and used so well, so even with hair problems, rehabilitation of the intestinal flora is an important measure so that the hair can be fully nourished again.

    In a double-blind, placebo-controlled study from 2013. It was also found in over 120 participants that using only probiotics (with L. reuteri) for 9 weeks could increase vitamin D levels by 25 percent – and there Healthy levels vitamin D. is also important for hair growth, probiotics they can also help here by a detour towards a faster goal and results.

    Vitamin deficiency in hair loss

    Deficiencies of vital substances can damage the hair structure and lead to diffuse hair loss, but they can also weaken the body, so other forms of hair loss are favored. Vitamin and mineral deficiencies are by no means common only in poor countries, which we would like to believe.

    In particular, hair follicles are among the most metabolically active areas in the body and are therefore particularly dependent on a sufficient amount of nutrients. A good supply of vital substances is therefore part of the concept of treating every type of hair loss.

    It would be ideal to first clarify which vitamins and / or minerals are actually lacking so that they can be targetedly added to the diet. If you simply take the preparations at random, you risk that the doses contained in them will not be enough to eliminate the possible deficiency. Most skin and hair supplements are insufficient.

    The exceptions are hair vitamins that are needed for optimal hair growth and good hair health, e.g. iron, zinc, selenium, vitamin A, vitamin E, vitamin B complex, vitamin C, biotin, millet extract, L-cysteine, etc.

    With vitamin A, care must be taken not to take an overdose, e.g. with offal, cod liver oil or other supplements, because too much vitamin A can cause hair loss!

    Zinc for hair loss

    Zinc deficiency can often be seen in patients with hair loss, which is why you should always check the status of zinc stores in case of hair loss. 2013 study confirmed frequent zinc deficiency in hair loss, while copper levels were normal.

    In 2013 It was determined that out of 312 patients with hair loss (circular hair loss, hereditary hair loss, diffuse hair loss), ALL had lower levels of zinc than the control group, which did not have hair loss.

    If hair loss is caused by zinc deficiency, it can be easily remedied by taking zinc supplements, as a small study from 2012 found. years. Even circular hair loss often improves significantly if there is a zinc deficiency, and then 50 mg of zinc is taken over a 12-week period, according to a 2009 study.

    It is not clear whether hair loss can be improved by giving zinc even if there was no previous zinc deficiency. The study showed that after zinc intake, hair loss can be reduced, even if a proven zinc deficiency cannot be determined.

    If you need zinc preparations with a higher dose and easily tolerated with zinc deficiency, we recommend chelated zinc , which provides 30 mg of zinc per capsule.

    Hair loss: iron, vitamin C and L-lysine

    Iron deficiency is a common cause of diffuse hair loss, especially in women, so iron levels (ferritin for iron storage) should be checked in any case, which you can do yourself with a home test for iron values.

    If you are looking for a well-tolerated iron supplement, purely herbal and without a prescription, here is a choice: 

    Iron from curry leaves (15 mg of iron per day) with vitamin C from acerola extract or

    chelated iron

    However, sometimes iron supplements simply do not work and it is difficult to raise the level of iron. The amino acid L-lysine can be used here as a support, because it helps in the absorption of iron and zinc.

    If you take L-lysine together with iron, the level of ferritin can increase more easily in this way, as shown by a study with patients with hair loss who did not react on their own to iron supplements.

    In order to improve the absorption of iron from plant foods, it is also important to optimize the supply of vitamin C, because vitamin C can greatly stimulate the absorption of iron, so vitamin C alone can often improve iron deficiency without the need for additional iron.

    Reach for fruits and vegetables rich in vitamin C or choose a natural vitamin C supplement  organic acerola powder which provides over 130 mg of vitamin C per gram.

    L-cysteine

    Another important amino acid in hair loss is L-cysteine. The amino acid that contains sulfur is needed to build keratin, the main component of our hair. L-cysteine provides resistance and strength of keratin and therefore can repair damaged hair structure, and can also be helpful in case of diffuse hair loss. The recommended minimum dose is 1400 mg of L-cysteine per day. 

    L-cysteine is contained in relatively small amounts in food, the steak gives only 240 mg of L-cysteine per 100 g. Rice protein also contains only about 200 mg per serving, hemp protein approximately 100 mg, so pure L-cysteine products would have to be used if you want to improve the disrupted keratin production with this amino acid.

    Is there a vitamin D deficiency in case of hair loss?

    In the case of existing hair loss (either circular, diffuse or similar), it should also be clarified whether there is a lack of vitamin D, because it can also encourage hair loss.

    2013. Researchers from the University of Cairo showed that women with diffuse hair loss have much lower levels of vitamin D (about 11 to 12 ng / ml) than women without hair loss. It was also noticed that the level of vitamin D was lower the more pronounced the hair loss and the longer this condition lasted.

    Do omega-3 fatty acids help with hair loss?

    The supply of essential fatty acids (omega-3 and omega-6) should be able to inhibit 5-alpha-reductase (an enzyme that converts testosterone to DHT), which would be significant given genetic hair loss.

    Gamma-linolenic acid is especially found in borage seed oil or black currant seed oil, which can be taken as a dietary supplement. Gamma-linolenic acid can also be produced by the body itself from linoleic acid (omega 6, eg in sunflower oil, safflower oil, etc.).

    Balance with omega-3 fatty acids is also important, because they are taken too little compared to omega-6 fatty acids.

    Vegan algae oil capsules  or fish oil capsules are recommended as a dietary supplement with omega-3 fatty acids.
    Due to the anti-inflammatory properties of omega-3 fatty acids that improve blood flow, such a dietary supplement also has an extremely positive effect on many other chronic ailments.

    Biotin for hair loss and loss

    Biotin is often taken for hair loss, and also for brittle nails. However, according to critics, biotin deficiency is rare because the intestinal flora can produce enough biotin. But it can only do so if it is in good condition, which is often no longer the case today, because there are too many harmful influences that affect the intestinal flora (antibiotics, other drugs, poor nutrition, chemicals from the environment, etc.).

    2017 Review He examined the literature on the effects of biotin on hair and nail growth. In all 18 cases in which patients received a dietary supplement with biotin, previously poor hair growth or previously poor nail quality improved. However, many subjects suffered from a deficiency of the enzyme that leads to biotin deficiency.

    Biotin participates in the good health of hair and scalp, but since many other vital substances are decisive, if there are other deficiencies, a dietary supplement with biotin alone will not help much, so you should always think about all the necessary vital substances.

    When buying a biotin supplement, pay attention to the dosage. Often only very small amounts of biotin are found.

    Silicon (silicon dioxide) is very important

    Unfortunately, silicon is a trace element to which too little attention is paid. In the body, it is mainly found in the bones, but also in the hair, nails, tendons and ligaments. In smaller quantities in soft tissue.

    If there is a tendency for hair loss, a lack of silicon stores can lead to more intense hair loss. Silicon is especially found in oats or brown millet, and also in nettles, but only in small amounts in other foods, so today’s common diet provides little silicon.

    Several studies have already indicated that silicon has a positive effect on hair health. For example, German scientists from the University Clinic in Hamburg-Eppendorf in 2007. published the results of research that daily intake of silicon significantly increased hair volume.

    The study participants were healthy women who complained of particularly thin hair. Since silicon is said to have a strong effect on hair structure, subjects should take 15 ml (1 tablespoon) of silicone gel daily for 6 months.

    After this time, it was found that not only did the hair volume increase, but that the health of the hair also benefited from the intake of silicon, which was reflected in the new shine and vitality of the hair.

    Three years later, researchers from the Karlsruhe city hospital reported similar results. Here, too, it has been proven that silicon (when taken 350 mg three times a day for 6 months) with previously reduced hair quality (brittle and dry hair) leads to clearly healthier, more beautiful and also thicker hair.

    The 2016 study presented two further studies that also found a significant improvement in hair and nail quality after taking silicon (10 mg daily for 9 months), which was not the case in the respective placebo groups. .

    Silicon can therefore be included in therapy in case of existing hair loss. The trace element can be used not only internally, but also externally.

    Internally, it is ideal without acids, and thus the basic colloidal silicone gel from GeoSilica.

    On the outside, hair growth concentrates containing silicon are applied to the scalp, which mineralize the skin, activate it and at the same time – if there is irritation – soothe it.

    Classical medicine and hair loss

    Conventional medicine also tries to discover the cause of hair loss, but in some cases several experts must be consulted: a dermatologist, an endocrinologist and sometimes a gynecologist.

    Finasteride is commonly used, especially in the case of genetically induced hair loss. It inhibits 5-alpha reductase, which would otherwise convert testosterone to DHT, thus reducing DHT levels.

    Side effects include decreased libido, erectile dysfunction to impotence and depression, which do not even disappear in any case after stopping the drug. Infertility, dry eyes and visual disturbances can also occur as side effects of taking finasteride.

    In addition, finasteride must be taken permanently, if you stop using the product, the hair will fall out again within a few weeks.

    Finasteride is not approved for women. Therefore, in case of androgenic hair loss, they are advised to use certain hormonal preparations or to use minoxidil, a solution that is applied to the scalp and which should show results after 6 months at the latest. Men can also massage them into the scalp twice a day in case of hair loss, but not if the scalp is reddened or otherwise irritated.

    However, it is these symptoms that are possible side effects of Minoxidil. It can dry out the skin, causing itching, redness and irritation, and also leads to rashes.

    Although a 2 percent solution of minoxidil is usually recommended for women, men take a five percent solution. Women should not take the latter, as they can lead to unwanted hair growth on other parts of the body (chest, legs, chin).

    Polycystic ovary syndrome successful natural treatment!

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    Polycystic ovary syndrome is the most common hormonal imbalance, affecting approximately 5-18% of women of reproductive age. This endocrine disorder is characterized by a heterogeneous clinical picture determined by different signs and symptoms, which makes diagnosis very difficult.

    Menstrual cycle dysfunction (oligo / anovulation)

    Clinical or biochemical hyperandrogenism (hirsutism, acne and / or alopecia).

    Ultrasound criteria (polycystic ovarian morphology)

    Polycystic ovary syndrome, symptoms:

    Very irregular menstrual cycles

    Amenorrhea

    Absence of menstruation. It occurs in 70% of cases.

    Oligomenorrhea

    Decreased menstruation (long cycles, greater than 35 days).

    Polymenorrhea

    Very frequent menstrual periods (short cycles, shorter than 25 days)

    Hypermenorrhea

    Prolonged, heavy and painful menstruation

    Premenstrual syndrome

    Premenstrual syndrome (PMS) is characterized by various physical changes (nausea, weight gain, fatigue, headaches, etc.) and mental (irritability, altered libido, depressed mood, behavioral changes …). These symptoms occur in the luteal phase of the menstrual cycle (a week before menstruation) and women with polycystic ovary syndrome tend to have a harder time withstanding them.

    Fertility problems

    Anovulation is the absence of ovulation and is one of the most common causes of female infertility.

    Excess androgens (hyperandrogenism) is an increase in the male hormone in the blood. Excess androgens can lead to hirsutism (increased body hair in areas such as the face or breasts), acne or seborrhea (excessive production of sebaceous glands) and / or acanthosis nigricans (presence of localized hyperpigmentation on the back of the head, armpits or wrinkles).

    Overweight women are more likely to suffer from polycystic ovary syndrome. Women with normal weight (BMI 18.5-25) also suffer from this syndrome. Therefore, it cannot be claimed with certainty that there is a direct link between being overweight and Polycystic Ovary Syndrome.

    Insulin resistance

    Insulin resistance code Polycystic ovary syndrome occurs due to a defect or inability of the muscle insulin receptor to capture glucose, which leads to an increase in blood glucose. Therefore, women with polycystic ovary syndrome are at increased risk of complications such as diabetes mellitus, premature atherosclerosis, hypertension, heart attack, abortion and coronary heart disease.

    The exact cause of polycystic ovary syndrome is unknown. Most experts agree that this is a multifactorial entity that is increasingly influenced by genetic factors. Genes associated with gonadotropins (hormones produced by the pituitary gland responsible for the release of the female hormones LH and FSH) and other hormones associated with insulin and its receptors have been identified.

    The most common causes

    Hormonal changes

    The pituitary gland is responsible for secreting female hormones luteinizing (LH) and follicle stimulating (FSH). In the case of Polycystic Ovary Syndrome, decompensation occurs in the production of these hormones and more LH is secreted than FSH (in normal situations, it should be the other way around). This decompensation leads to increased androgen production. Elevated levels of the male hormone can prevent the separation of the egg from the ovary (prevent ovulation) and disrupt the female menstrual cycle.

    Hyperinsulinemia

    Insulin is a hormone produced by the pancreas that is involved in the metabolic use of nutrients and is responsible for regulating the amount of glucose in the blood until it is converted into energy. In women with Polycystic Ovary Syndrome, changes in insulin receptors have been observed, leading to an increase in blood glucose. The pancreas as a compensatory response produces more insulin and this overproduction has direct effects on the ovary. Excess testosterone levels are produced and typical signs of the syndrome are generated (hirsutism, anovulation, acne, etc.)

    It is important to consider other causes such as stress, emotions, diet and an inactive lifestyle because they can affect and cause changes in the hormonal system.

    Fertility, pregnancy and PCOS

    Fertility

    Women with polycystic ovary syndrome have problems with the menstrual cycle (anovulation is the leading cause of infertility in these patients). Insulin resistance and associated changes in endometrial development may adversely affect fertility. Approximately 85-90% of women who do not ovulate and want to get pregnant go to in vitro fertilization centers, although that does not mean that they cannot get pregnant naturally. 60% of women with Polycystic Ovary Syndrome are fertile and can become pregnant in less than 12 months. The chances of getting pregnant spontaneously are reduced if you have oligoovulation.

    Pregnancy

    Women with polycystic ovary syndrome have a higher risk of certain complications during pregnancy (gestational diabetes, hypertension, preeclampsia, premature birth). Common diseases such as metabolic syndrome (insulin resistance) and hyperandrogenism can increase the risk of pregnancy. Several studies claim that babies are more likely to be older for their gestational age and will suffer a spontaneous caesarean section or suffocation during birth.

    Diet and Polycystic Ovary Syndrome

    The most effective treatment for Polycystic Ovary Syndrome is to lead a healthy lifestyle accompanied by a balanced diet and regular physical activity.

    Recommended diet

    Whole carbohydrates

    Consumption of whole grains can reduce the risks of inflammation and obesity that characterize the development of insulin resistance. Cereals contain fiber and a lower glycemic index, slightly raising blood glucose levels, unlike refined or simple sugars. It is advisable to include in your diet the consumption of cereals such as quinoa, buckwheat, millet, oats, amaranth.

    What is the glycemic index (GI)? Can the GI of food be altered?

    The glycemic index is the ability of foods to raise blood glucose.

    Hydration, maturation and heat have the ability to increase the GI in food. It is recommended to avoid too long cooked foods: rice, white pasta and potatoes, sweet potatoes because they raise blood glucose faster (it is better to cook “al dente”).

    Fruits and vegetables

    Fruits and vegetables are rich in vitamins, fiber, minerals and antioxidants. Its consumption is necessary for a healthy and balanced diet. They have a very low caloric value, are well satiated, reduce appetite and are therefore recommended in all diets for weight loss.

    Fruit

    The fruit has a very variable GI which can be high -medium -low. Fruits consumed with the skin (strawberries, blueberries, cherries) tend to have a lower GI than those fruits that are eaten without the skin (watermelon, pineapple, mango, etc.). It is recommended to avoid consuming dehydrated fruit, fruit in the form of syrups as well as natural juices with artificial sweeteners.

    Vegetables

    Vegetables can be classified according to their starch content. Starchy vegetables (pumpkin, peas, carrots) have a higher glycemic index, so they can raise blood glucose more than those that do not contain it (green leafy vegetables, peppers, zucchini, peppers, etc.)

    Fruit juice is not equivalent to a portion of fruit, no matter how natural it is. When we process the fruit (cut it, peel it, squeeze it, etc.), approximately 50% of vitamins and minerals are lost along with the fiber.

    The fruit contains natural sugar, but it also contains other nutrients that provide numerous benefits to our health if we consume it unprocessed. If we take it in the form of juice, because it does not contain pulp or fiber, it raises blood glucose levels faster.

    We have to chew the whole fruit, it gives us more satiety than the intake of juice, which is quickly absorbed and digested. You should always give priority to consuming whole fruits over juices. You do not have to eliminate vegetables that contain starch from your diet, but it is recommended to include them in your diet in small quantities.

    Legumes

    legumes

    Legumes are rich in fiber and have a low GI, in addition to providing satiety, they are associated with weight loss. In several studies, it has been noticed that their regular consumption (at least 2-3 times a week) can help increase the levels of the transport protein SHBG (sex hormones), which would help reduce the levels of free testosterone in the blood.

    Proteins

    Proteins do not raise insulin levels like carbohydrates. Their consumption is associated with weight and fat loss, as well as with the stabilization of blood sugar levels. Proteins are found in foods of animal and plant origin (legumes, nuts, tofu …). There is no standard protein intake. Your recommendation should be personalized, because it varies depending on the intensity and type of sport you play. Although not standardized, several studies have found that consuming about 1.8-2g / kg / day of protein has positive effects on weight loss.

    Healthy fats

    Omega-3 fats are essential because they improve insulin sensitivity and blood cholesterol levels. Women with polycystic ovary syndrome can have very high levels of prolactin (a hormone produced by the pituitary gland), which leads to changes in the menstrual cycle (anovulation) and possible fertility problems. It is necessary to include the consumption of healthy fats in order to increase the level of HDL cholesterol, which is necessary for optimal hormone production (all sex hormones come from cholesterol). Healthy fats are found in walnuts, seeds, egg yolks, avocados or extra virgin olive oil.

    Not recommended foods:

    Simple carbohydrates

    Simple carbohydrates quickly raise blood glucose levels by increasing insulin resistance and body weight. We can find them in ultra processed products such as pastries, sweet cereals, chocolate, ice cream, pastries, sweets, soft drinks.

    Refined carbohydrates

    Refined carbohydrates are low in nutrients. They do not provide many nutrients other than starch. By purifying them, in addition to fiber, large amounts of microelements are lost, which makes them useless food. Like simple carbohydrates, they raise blood glucose levels, but not as fast. More energy is needed to process them. White bread, pasta, rice and sweet cereals would be examples of simple carbohydrates.

    Pastry

    Pastries are enriched with sugars, saturated or trans fats and refined flour. They have a high GI that worsens insulin resistance, and its consumption is especially counterproductive in women who suffer from Polycystic Ovary Syndrome. Examples are sweets, cookies and pastries.

    Fruit juices

    Fruit juices do not saturate, are easily digested, quickly raise blood glucose levels and contain almost no vitamins. It is better to opt for a whole piece of fruit and reduce the use of juices, regardless of whether they are natural or not.

    Milk

    There is a lot of controversy and discussion regarding milk consumption. There is evidence that milk, especially skim milk, can contribute to an increase in androgens, worsening acne and hirsutism. This association was not found in fermented dairy products, because they generate less activation of IGF-1. In conclusion, it is advised to limit the consumption of milk and increase the consumption of fermented dairy products (kefir) or herbal drinks without added sugar.

    Soft drinks and alcohol

    They raise the level of glucose in the blood, worsen insulin resistance and their consumption seriously harms our health.

    Vitamins to consider

    Inositol

    A substance that belongs to the B group of vitamins and provides numerous benefits: it helps regulate hormonal cycles (reduces the level of free testosterone and increases the level of LH), improves hirsutism and acne, and intervenes in the metabolism of sugar and fat in favor of weight loss. It has been determined that taking 3-4 g of inositol a day increases insulin sensitivity and improves ovulation. Foods that contain: citrus fruits, legumes, nuts.

    Folic acid

    Folic acid

    Vitamin B9 supplementation can help treat ovulatory infertility. Several studies have shown that the addition of vitamin B9 together with inositol has a positive effect on women and regulates their menstrual cycle. Green leafy vegetables and legumes are rich in folic acid.

    Vitamin D

    Vitamin D deficiency is associated with increased insulin resistance and weight gain. Sun exposure is a major factor in the production of calciferol (vitamin D3). It can also be found in foods such as dairy products, oily fish and egg yolks.

    Polycystic ovary syndrome and physical activity

    The impact of physical exercise on women with Polycystic Ovary Syndrome provides a number of benefits:

    Improves emotional state (depression, anxiety, mood swings …)

    Increases insulin sensitivity

    Improves the hormonal profile of LH / FSH

    Increasing SHBG helps reduce testosterone levels in the blood

    Weight loss and body fat

    Reduces and improves premenstrual pain

    Biological therapies for cancer application research

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    Biological therapy uses living organisms, substances from living organisms or synthetic versions of such substances to treat cancer.

    Some types of biological therapy use the natural ability of the immune system to detect and destroy cancer cells, while other types directly target cancer cells.

    Biological therapies include monoclonal antibodies, cytokines, therapeutic vaccines, Bacillus Calmette-Guerin bacteria, viruses that kill cancer cells, gene therapy, and adopted T lymphocyte transmission.

    Side effects of biological therapies can vary depending on the type of treatment, but reactions at the site of application are quite common with these treatments.

    What is biological therapy?

    Biological therapy involves the use of living organisms, substances derived from living organisms or laboratory-produced versions of such substances for the treatment of disease. Some biological cancer therapies stimulate the body’s immune system to act against cancer cells. These types of biological therapies, sometimes collectively referred to as “immunotherapy,” do not directly attack cancer cells. Other biological therapies, such as antibodies, attack directly cancer cells . Biological therapies that interfere with certain molecules involved in tumor growth and evolution are also called targeted therapies.

    For cancer patients, biologic therapies can be used to treat the cancer itself or the side effects of other cancer treatments. Although many forms of biological therapy have already been approved by the Food and Drug Administration (FDA), others are still experimental and available to cancer patients primarily through participation in clinical trials (research studies involving humans).

    What is the immune system?

    Immune system is a complex network of cells, tissues, organs and matter that they produce. It helps the body fight infections and other diseases.

    White blood cells or leukocytes are primarily involved in the responses of the immune system. These cells perform many tasks necessary to protect the body from microbes and abnormal cells that cause disease.

    Some types of leukocytes roam the circulatory system in search of foreign invaders and diseased, damaged or dead cells. These white blood cells provide a general – or non-specific – type of immune protection.

    Other types of white blood cells, known as lymphocytes, provide targeted protection against certain threats, either from a specific microbe or from a diseased or abnormal cell. The most important groups of lymphocytes responsible for these specific immune responses are B lymphocytes and T lymphocytes.

    B cells produce antibodies, which are large secreted proteins that bind to foreign intruders or abnormal cells and help destroy them.

    Other types of lymphocytes and leukocytes have supporting functions to ensure that B cells and cytotoxic T cells do their job efficiently. These support cells include helper T lymphocytes and dendritic cells, which help activate both B lymphocytes and cytotoxic T lymphocytes and facilitate their response to specific microbial threats or diseased or abnormal cells.

    Antigens are substances in the body that accompany their own cells and microbes that can be recognized by the immune system as harmful to our body. Normal cells in the body have antigens that identify them as “themselves”. Self antigens tell the immune system that normal cells do not pose a threat and should be ignored. In contrast, the immune system recognizes microbes as a possible threat that must be destroyed because they carry foreign antigens or they are not theirs. Cancer cells also often contain antigens, called tumor antigens, that are not present (or are present in lower concentrations) in normal cells.

    Can the immune system attack cancer?

    The natural ability of the immune system to detect and destroy abnormal cells probably prevents or suppresses the formation of many cancers. Immune cells can sometimes be found in or near tumors. These cells, called lymphocytes that infiltrate the tumor or TIL, are an indication that the immune system is responding to mutated cells. The presence of TIL in a patient’s tumor is often associated with a better patient treatment outcome.

    However, cancer cells have a number of ways to avoid detection and destruction by the immune system. For example, cancer cells can:

    They undergo genetic changes that reduce the expression of tumor antigens on their surface, making them less “visible” to the immune system.

    They have proteins on their surface that inactivate immune cells.

    They induce normal cells around the tumor (i.e. in the microenvironment of the tumor) to release substances that suppress the immune response and that promote cell proliferation and tumor survival.

    Immunotherapy uses several methods to strengthen the immune system and / or help to overcome cancer defense against the immune system. The goal is to improve the ability of the immune system to detect and destroy cancer.

    What types of biological therapies are used to treat cancer?

    Several types of biological therapies, especially immunotherapy, are used or formulated to treat cancer. These therapies fight cancer in different ways.

    Immune checkpoint inhibitors

    How do they work? This type of immunotherapy releases the “brake” of the immune system, which usually prevents excessively strong immune reactions that could damage normal cells as well as abnormal cells. This brake involves proteins on the surface of T lymphocytes called immune checkpoint proteins. When immune checkpoint proteins recognize specific accompanying proteins in other cells, a shutdown signal is sent telling T lymphocytes not to trigger an immune response against those cells.

    Two proteins that have been studied very extensively are PD-1 and CTLA-4. Some tumor cells express high concentrations of the accompanying PD-1 protein PD-L1, which causes T lymphocytes to “shut down” and help cancer cells avoid immune destruction. Also, interactions between B7 protein on cell antigen and CTLA-4 are expressed in T cells to prevent other T cells from destroying cells, including cancer cells.

    Drugs called immune checkpoints (or modulators of immune checkpoints) prevent the interaction between immune checkpoint proteins and their accompanying proteins, facilitating a strong immune response. The current targets of checkpoint inhibitors are PD-1, PD-L1, and CTLA-4.

    How to use:

    immune checkpoint inhibitors are approved for the treatment of various types of cancer, including skin cancer, non – lung cancer, small cell lung cancer, bladder cancer, head and neck cancer, liver cancer, Hodgkin ‘s lymphoma, renal cell carcinoma (kidney cancer type) and gastric cancer. An immune checkpoint inhibitor, pembrolizumab (Keitruda®), is used to treat any solid tumor that has high microsatellite instability or cannot be removed surgically. Another immune checkpoint inhibitor, nivolumab (Opdivo®), is used to treat repair abnormalities and major microsatellite instability and metastatic colon cancer that has progressed after treatment with fluoropyrimidine, oxaliplatin, and irinotecan.

    Immune cell therapy (also called adopted cell therapy or adopted immunotherapy)

    How does it work? This method allows the patient’s own immune cells to attack tumors. There are two methods of cell therapy used to treat cancer. Both involve collecting the patient’s immune cells, multiplying a large number of these cells in the laboratory, and bringing the cells back into the patient.

    Lymphocytes that infiltrate the tumor (or TIL). This method uses T lymphocytes that are naturally found in the patient’s tumor, called tumor infiltrating lymphocytes (TIL). TILs that best recognize a patient’s tumor cells in laboratory tests are selected, and these cells are grown in large numbers in the laboratory. The cells are then activated by treatment with signaling proteins of the immune system called cytokines and injected into the patient’s bloodstream.

    The idea behind this method is that TILs have already shown the ability to target tumor cells, but there may not be enough of them in the tumor microenvironment to destroy the tumor or overcome the suppressive immune signals that the tumor emits. The introduction of huge amounts of activated TILs can help overcome these barriers.

    T and CAR cell therapy

    This method is similar, but the patient’s T cells are genetically modified in the laboratory to express a protein known as a chimeric antigen receptor or CAR, before being grown and injected into the patient. CARs are modified forms of a protein called the T-cell receptor, which is expressed on the surface of T-cells. CARs are designed to allow T cells to adhere to certain proteins on the surface of a patient’s cancer cells, which improves his ability to attack cancer cells.

    Before receiving expanded T cells, patients also undergo a procedure called lymphatic depletion, which consists of a round of chemotherapy and, in some cases, whole-body radiation. Lymphatic depletion kills other immune cells that can interfere with the efficiency of incoming T cells.

    How to use? The adopted T cell transfer was first studied for the treatment of metastatic melanoma because melanomas often cause a significant immune response, with many TILs. The use of activated TILs has been effective for some patients with melanoma and has given encouraging positive results in other cancers (e.g., cervical squamous cell carcinoma and cholangiocarcinoma).

    Two T and CAR lymphocyte therapies were approved. Tisagenlecleucel (Kimriah ™) is approved for the treatment of some adults and children with acute lymphoblastic leukemia who do not respond to other treatments and for the treatment of adults with some types of non-Hodgkin’s B-cell lymphoma who have not responded or relapsed in at least two other treatments. In clinical studies, many cancer patients have completely disappeared, and several of these patients have been without cancer for a long time. Ciloleucel akicabtagene (Iescarta () is approved for patients with certain types of non-Hodgkin B cells who have not responded or have relapsed after at least two other treatments. Both therapies involve modifying the patient’s own immune cells.

    Therapeutic antibodies

    How do they work? Therapeutic antibodies are laboratory-made antibodies that are designed to kill cancer cells. They are a type of cancer-targeted therapy – drugs specifically designed to interact with a specific molecule (or “molecular target”) necessary for cancer cell growth.

    Therapeutic antibodies work in many different ways:

    They can interfere with a key signaling process that promotes cancer growth and alerts the immune system to destroy cancer cells to which antibodies bind. An example is trastuzumab (Herceptin), which binds to a protein in cancer cells called HER2.

    Adherence to the target protein can directly lead to the transition of cancer cells to apoptosis. Examples of this type of therapeutic antibody are rituximab (Ritukan®) and ofatumumab (Arzerra®), which attack a protein on the surface of B lymphocytes called CD20. Similarly, alemtuzumab (Campath®) binds to a protein on the surface of mature lymphocytes called CD52.

    They can be bound to a toxic substance that kills the cancer cells to which the antibody binds. A toxic substance can be a poison, such as a bacterial toxin; small molecule drug; a light-sensitive chemical compound (used in photoimmunotherapy); or a radioactive compound used in radioimmunotherapy). Antibodies of this type are sometimes called antibody-drug conjugates (ADCs). Examples of ADCs used for cancer are ado-trastuzumab emtansine, ado-trastuzumab emtasine (Kadcila®), which is taken and destroyed by cancer cells that express HER2 on their surface, and brentuximab vedotin (Adcetris®), which are absorbed by lymphoma cells that surfaces express CD30 and destroy them.

    They can bring activated T lymphocytes closer to cancer cells. For example, the therapeutic antibody blinatumomab (Blincito®) binds both to CD19, a tumor-associated antigen that is overexpressed on the surface of leukemia cells, and to CD3, a glycoprotein on the surface of T cells that is part of the T lymphocyte receptor. Blinatumomab contacts leukemia cells with T lymphocytes, resulting in activation of T lymphocytes and cytotoxic T lymphocytes against CD19-expressing leukemia cells.

    Other immunotherapies combine other molecules of the immune system (which are not antibodies) and substances that destroy cancer. For example, denileucine diphthytox (ONTAK®) contains interleukin-2 (IL-2) bound to a toxin produced by the bacterium Corinebacterium diphtheria, which causes diphtheria. Denileukin diphtheria uses its share of IL-2 to attack cancer cells that have IL-2 receptors on their surface, allowing the diphtheria toxin to destroy them.

    How are they used? Many therapeutic antibodies are approved for the treatment of a wide range of cancers.

    Therapeutic vaccines

    How do they work? Cancer vaccines are designed to treat existing cancers by strengthening the body’s natural defenses against cancer. The purpose is to slow or stop the growth of cancer cells; to shrink the tumor; stopping the recurrence of cancer; destruction of cancer cells that are not killed by other forms of treatment.

    The purpose of cancer vaccines is to introduce one or more cancer antigens into the body that cause an immune response that eventually destroys the cancer cells.

    Vaccines for the treatment of cancer can be made from the patient’s own cells (that is, they are modified in such a way as to create an immune response to characteristics that are unique to the patient’s specific tumor) or from substances (antigens) produced by certain types of tumors. , they generate an immune response in each patient whose tumor produces antigen).

    The first FDA-approved cancer vaccine, sipuleucel-T (Provenge®), is tailored for each patient. It is designed to stimulate the immune response to prostate acid phosphatase (PAP), an antigen found in most prostate cancer cells. The vaccine is made by isolating immune cells called dendritic cells, which are a type of antigen-presenting cell (APC), from a patient’s blood. These cells are sent to a vaccine manufacturer, where they are grown together with a protein called PAP-GM-CSF. . This protein consists of PAPs associated with a protein called granulocyte macrophage colony stimulating factor (GM-CSF), which stimulates the immune system and improves antigen presentation.

    Cells representing antigens cultured PAP-GM-CSF are the active component of sipuleucel-T. These cells are injected into the patient. Although the exact mechanism of action of sipuleucel-T is not known, APC cells that have occupied PAP-GM-CSF appear to stimulate T lymphocytes of the immune system to kill PAP-expressing tumor cells.

    The first FDA-approved oncolytic viral therapy, talimogen laherparepvec (T-VEC or Imligic®), is also considered a type of vaccine. It is based on the herpes simplex virus type 1 and includes a gene that encodes GM-CSF. Although this oncolytic virus can infect both cancer cells and normal cells, normal cells have mechanisms to destroy the virus, while cancer cells do not. T-ECV is injected directly into the tumor. As the virus replicates, it causes the cancer cells to explode and die. Dying cells release new viruses, GM-CSF and various tumor-specific antigens. They can stimulate an immune response against cancer cells throughout the body.

    How are they used? Sipuleucel-T is used to treat prostate cancer that has metastasized in men who have few or no symptoms and whose cancer is hormone resistant (does not respond to hormonal treatment). ECV-T is used to treat some patients with metastatic melanoma that cannot be removed surgically.

    Substances that modulate the immune system

    How do they work? Substances that modulate immunity strengthen the body’s immune response against cancer. These substances include proteins that usually help regulate or modulate the activity of the immune system, microbes and drugs.

    Cytokines These signaling proteins are naturally produced by white blood cells. They help mediate and fine-tune immune responses, inflammation and hematopoiesis (formation of new blood cells). There are two types of cytokines used to treat cancer patients: Interferon Interferons (INF) and Interleukins (IL). The third type, called hematopoietic growth factor, is used to control some of the side effects of some chemotherapy regimens.

    The researchers found that one type of interferon, interferon-α, can improve a patient’s immune response to cancer cells by activating some white blood cells, such as natural killer cells and dendritic cells. Interferon-α can also inhibit the growth of cancer cells or accelerate their death.

    Researchers have identified more than a dozen different interleukins, including interleukin-2, also called T-cell growth factor. Interleukin-2 is naturally produced by activated T cells. It increases the proliferation of white blood cells, including cytotoxic T lymphocytes and natural killer cells, resulting in a better immune response against cancer. Interleukin-2 also facilitates the production of antibodies by B lymphocytes for further attack on cancer cells.

    Hematopoietic growth factors are a special class of natural cytokines. They promote the growth of different populations of blood cells that are depleted by chemotherapy. Erythropoietin stimulates the production of red blood cells, and interleukin-11 increases platelet production. Granulocyte macrophage colony stimulating factor (GM-CSF) and granulocyte colony stimulating factor (G-CSF) stimulate lymphocyte growth, reducing the risk of infection.

    Granulocyte colony stimulating factor and granulocyte-macrophage colony stimulating factor may also enhance specific anticancer responses of the immune system by increasing the number of cancer-fighting T lymphocytes.

    Bacillus of Calmette-Guerin (BCG). The weakened form of live TB bacteria does not cause disease in humans. It was first used in medicine as a vaccine against tuberculosis. When inserted directly into the bladder with a catheter, the Calmette-Guerin bacillus stimulates a general immune response that is directed not only at the foreign bacteria themselves but also at the bladder cancer cells. The exact mechanism of this anticancer effect is not well understood, but treatment is effective.

    Immunomodulatory drugs (also called biological response modifiers). These drugs are powerful modulators of the body’s immune system. They include thalidomide (Thalomid®); lenalidomide (Revlimid®) and pomalidomide (Pomalist®), thalidomide derivatives having a similar structure and function; and imiquimod (Aldara®, Ziclara®).

    It is not entirely clear how thalidomide and its two derivatives stimulate the immune system, but they promote the secretion of IL-2 from cells and inhibit the ability of tumors to form new blood vessels that support their growth (a process called angiogenesis). Imiquimod is a cream that is applied to the skin. It causes cells to release cytokines, especially INF-α, IL-6 and TNF-α (a molecule that participates in inflammation).

    How are they used? Most substances that modulate the immune system are used to treat advanced cancer. Some are used as part of a support scheme. For example, recombinant and biologically similar forms of GM-CSF and G-CSF are used in combination with other immunotherapies to boost the immune response against cancer by stimulating white blood cell growth.

    What are the side effects of biological therapies?

    The side effects of biologic therapies generally reflect immune system stimulation and may vary according to the type of therapy and the way individual patients respond to it.

    However, pain, inflammation, irritation, redness of the skin, itching and rash at the site of infusion or injection are quite common with these treatments. They can also cause a variety of flu-like symptoms, including fever, chills, weakness, dizziness, nausea or vomiting, muscle or joint pain, fatigue, headaches, occasional shortness of breath, and high or low blood pressure. Some immunotherapies that trigger an immune system reaction also cause a risk of hypersensitivity reactions (allergies), even fatal ones.

    Long-term side effects (especially immune checkpoint inhibitors) include autoimmune syndromes and acute onset diabetes.

    Possible serious side effects of immunotherapy are:

    Immune checkpoint inhibitors

    Reactions that damage organs caused by immune activity and include the digestive system, liver, skin, nervous system, heart and glands that produce hormones. These reactions can cause pneumonitis, colitis, hepatitis, nephritis and renal failure, myocarditis (inflammation of the heart muscle), hypothyroidism and hyperthyroidism.

    Immune cell therapy

    Cytokine release syndrome (CAR and T cell therapy)

    Capillary leak syndrome (TIL therapy)

    Therapeutic antibodies and other immune system molecules

    Cytokine release syndrome (blinatumomab)

    Infusion reactions, capillary leakage syndrome and poor visual acuity (denileucine diphthotox)

    Therapeutic vaccines

    Flu-like symptoms

    Severe allergic reaction

    Stroke (sipuleucel-T)

    Tumor lysis syndrome, herpes viral infection (T-VEC)

    Immune system modulators

    Flu-like symptoms, severe allergic reaction, low blood counts, changes in blood chemistry, organ damage (cytokines)

    Flu-like symptoms, severe allergic reaction, urinary side effects (BCG)

    Serious birth defects if taken during pregnancy, blood clots, venous embolism, neuropathy (thalidomide, lenalidomide, pomalidomide)

    Skin reactions (imiquimod)

    What are the current research on cancer immunotherapy?

    Researchers are focusing on several important fields to improve the effectiveness of cancer immunotherapy, including:

    Methods for overcoming resistance to cancer immunotherapy. Researchers are testing combinations of different immune checkpoint inhibitors, as well as immune checkpoint inhibitors in combination with a wide range of other immunotherapies, molecularly targeted cancer therapies and radiation, as ways to overcome therapeutic drug resistance. Tumors on immunotherapy.

    Identification of biomarkers that predict response to immunotherapy. Not everyone receiving immunotherapy will respond to treatment. Identification of biomarkers that predict the response is the main field of research.

    Identification of new cancer-related antigens – so-called neoantigens – that may be more effective in stimulating immune responses than known antigens.

    Non-invasive strategies for isolating immune cells that respond to tumors that express neoantigens.

    Understand better the mechanisms by which cancer cells avoid or suppress the immune response against cancer. A better understanding of how cancer cells manipulate the immune system could lead to the formulation of drugs that block these processes.

    Proximity to infrared photoimmunotherapy. This method uses infrared light to activate targeted destruction of cancer cells in the body (December 14-14).

    Where can I find information on immunotherapy clinical trials?

    In clinical trials, they are evaluated and approved by the FDA and experimental immunotherapy for certain types of cancer. Descriptions of ongoing clinical trials examining the types of immunotherapy in cancer patients can be found in the List of Cancer Clinical Trials on the NCI website. The NCL clinical trial list includes all NCI-sponsored clinical trials conducted in the United States and Canada, including at the NIH Clinical Center in Bethesda, Maryland. For information in English on other ways to search the list, see Help Find NCI-Supported Clinical Trials.

    Otherwise, call the NCI Contact Center at 1-800-422-6237 (1-800-4-RAK) for information on clinical trials of immunotherapies.

    Infertility and its natural treatment

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    Infertility in its symptoms, there are every tenth couple who want children. Fertility declines in both sexes after 25-30 years of age. More and more couples are delaying starting a family until they are in their thirties, so infertility is becoming more common in the developed world. If conception has not occurred after a year of regular unprotected sex, it is possible that one or both partners need to be treated for infertility.

    About 8 to 10 couples who try to conceive a child succeed in that during one year. That number rises to 9 out of 10 couples over a two-year period. The problem of conception can be temporary, or the couple must treat infertility to have children. The problem of infertility also occurs in people who already have children.

    Both partners must visit the doctor together if they are worried about the inability to conceive a child. In about half of couples with this problem, infertility exists in women, and in a third of couples, the problem exists in men. In some couples, however, the cause can be discovered.

    Women’s problems that most often lead to infertility are: ‘Polycystic ovary syndrome, Endometriosis, Varicocele, Hypogonadism’ and others.

    In many couples, the cause of infertility can be identified and treated. If a specific cause cannot be detected and treated, assisted (artificial) conception with modern medical techniques is advised.

    Problems conceiving

    fetal infertility
    • When pregnancy is not the result of regular unprotected sex for more than a year

    On average, one couple trying to conceive a child takes six months, and 8 to 10 couples succeed in doing so over the course of a year. It is common for a couple to worry if the pregnancy does not follow in the first few months, but most young couples are advised to keep trying for a year before seeking medical help. Older couples, especially when a woman is older than 35, may seek medical help earlier because fertility naturally declines with age, especially in women.

    What to do?

    • Modern medicine or look for a cure in nature?

    If you have problems conceiving, you and your partner should see a doctor together. Your doctor will ask you questions about your sex life and whether you have any specific problems with sexual intercourse. They will probably ask you if you had sexual intercourse during the most favorable days – in the middle of the menstrual cycle when the chances of conception are usually the highest. Your doctor will look at your health record because previous illnesses or surgeries may be significant to your problem. It will consider how often you drink alcohol, whether you are a smoker, whether you use some medications prescribed to you, or some relaxation medications. Regular physical examination is mandatory, which includes an examination of the genitals.

    If you are both relatively young and there is no obvious problem, your doctor will advise you on the measures you will take to increase the likelihood of conception and suggest that you keep trying. If you have not gone to healthy pregnancy counseling before, your doctor will talk to you about your health, diet, and lifestyle.

    When the doctor suspects that there is a problem that prevents conception, or if the woman is older than 35, he will refer you to a specialist doctor to perform a series of tests.

    Prognosis for infertility

    Statistics performance

    It is only a matter of time before conception occurs for most couples. 9 out of 10 couples manage to conceive a child within two years.

    If a problem is found, the treatment and prospects will depend on the sample. Assisted conception, i.e., artificial insemination, may be suitable for couples in whom the cause has not been identified or the problem cannot be successfully treated.

    How can you help yourself?

    How to increase the chances of conception?

    The overall health of both partners has an important effect on fertility. The following factors can play an important role in creating a conception:

    • Check your body weight – whether you are overweight or obese
    • Eat healthily
    • Don’t smoke
    • Reduce alcohol intake, which is known to reduce sperm count and can harm the fetus if pregnancy begins
    • Have sex every two days during a woman’s most fertile period (mid-menstrual cycle)
    • Try not to worry because stress can reduce fertility.
    • Do sports or recreation.
    • Men should avoid bathing in hot water, saunas, and hot baths or wearing tight and tight underwear.

    Infertility in women

    The inability of a woman to conceive with a partner of normal fertility

    One of the factors that can affect women’s infertility is: ‘Age – more common in women over 35, hereditary factor, lifestyle – stress, excessive physical exercise and low or overweight’.

    Nowadays, the percentage of infertility in women is still slightly higher than in men. To conceive, the ovary must release mature eggs that the sperm will fertilize, and the fertilized egg must pass through the fallopian tube to the uterus and implant itself in its mucous membrane. If one of the conception processes in a woman is endangered, a problem arises.

    Causes of infertility in women

    There are a number of infertility problems in women and they can affect one or more processes necessary for conception. Problems can arise at different stages of conception.

    Ovulation problems

    A common cause of infertility in women is ovarian failure to release a mature egg during the menstrual cycle. Complex hormone relationships control ovulation, so a healthy hormonal balance is essential.

    One of the most commonly cured causes of infertility in women is polycystic ovaries, which can cause hormone imbalances that prevent ovulation.

    Also, thyroid disorder (hypothyroidism) can cause ovulation failure.

    In some cases where women use contraceptives, there may be a lack of cycles after using them.

    Problems with egg transfer

    Damage to one of the fallopian tubes can make it difficult for the egg to pass from the ovary to the uterus. The cause of damage to the fallopian tubes can be a pelvic infection, which can be a consequence of sexually transmitted diseases such as chlamydia. Such infections can go unnoticed in a woman’s body for a long time and can be detected in problems with conception. In some women, the egg cannot be fertilized because the mucus that the cervix naturally produces contains antibodies that destroy the partner’s sperm before they reach the egg, or is too thick to allow sperm to enter the uterus.

    What women should do

    Certainly, if there is a problem, the woman should consult a doctor who should conduct a basic and systematic analysis of the overall situation. Basically, each analysis begins with an overview of a woman’s general health, lifestyle, medical history, menstrual cycles, and analysis of sex life.

    Most causes of infertility can be determined with the help of tests or with the help of ovulation prediction devices, which can be bought without a prescription in a pharmacy.

    When all home methods do not give results, you should switch to professional medical blood tests, ultrasound examinations of the ovaries during the cycle, examining the uterus, hormonal analyses, and the like.

    Success rate for treating female infertility

    Treatment of infertility in women has significantly increased the chances of pregnancy. The success rate varies depending on the cause of infertility and the type of treatment. The drugs are used to stimulate ovulation in every third woman. Still, there is a risk of ectopic pregnancy Microsurgery, which cleans, i.e., bloating, blocked fallopian tube, sometimes successful, but increases the risk of ectopic pregnancy. The success rate in the assisted conception method varies from 15-30% per individual method.

    What is happening nowadays is that after a detailed analysis of a woman, it is concluded that the problem is with a man—sperm he produces.

    Infertility in men

    What is male infertility?

    A man’s inability to produce or deliver a sufficient number of healthy sperm to fertilize.

    One of the most common causes of male infertility is hereditary factors, smoking, and alcohol. Age and chromosome abnormalities are less likely to be the causes.

    Approximately every third couple who has difficulty conceiving the problem stems from male infertility. In men, fertility depends on the production of a sufficient amount of normal sperm and in part on men’s ability to deliver sperm to the vagina during sexual intercourse. If any of these conditions are not met, we can talk about infertility.

    Causes of infertility in men

    Unlike the cause of infertility in women, which is easier to determine, in some men it is difficult to find the cause of infertility. It is detected only in every third man examined.

    Problems with sperm production

    sperm and infertility

    Decreased sperm count (Oligospermia) or the formation of defective sperm may have different patterns. Under normal conditions, the testicles have about 2 ° C lower body temperature than the rest of the body. All factors that increase testicular temperature can reduce the number of sperm produced.

    Some aspects of life can damage sperm production, such as smoking, alcohol, certain medications and medications for relaxation, and even wearing tight clothing.

    Some long-term diseases adversely affect the production of sperm, such as chronic kidney disease, infections, mumps after puberty, and the like. Male fertility can also be reduced by diseases of the urinary tract, diseases of the scrotum, or damage to the testicles during a surgical intervention. Also, hormonal disorders in men can lead to a decrease in the number of sperm as well.

    Sperm ejection problems

    Several factors can prevent sperm from reaching the vagina. The cause that is most easily blamed is impotence, i.e., inability to achieve or maintain an erection. Other factors include damage to the testicles and vas deferens. A sexually transmitted disease, such as gonorrhea often causes such damage. Also, the causes can be retrograde ejaculation – when the seminal fluid returns to the bladder because the bladder valves are not well closed, which can happen after prostate surgery.

    What can be done

    As with women, each doctor will immediately perform a basic analysis of general life, physical condition, sex life, and how a man lives. In addition to examining the genitals, laboratory analysis of semen – a program is mandatory. Semen analysis is performed microscopically where the number of sperm per milliliter is actually seen. The normal number of sperm is about 50 million, while the small number (oligospermia) is about 20 million per milliliter.

    How to treat Oligospermia in men?

    In addition to artificial insemination, there are drugs in modern medicine that act on a reduced number of sperm. They are mainly related to hormone therapies.

    When it comes to natural therapy, there are various preparations, but the market has a completely natural tea blend of medicinal herbs Oligo. Oligo tea against male infertility is one of the premium products of domestic Serbian company Chamomilla from Banatski Karlovac, which has been selling and producing medicinal plant products on the Serbian market for 30 years. The family company Chamomilla produces teas, tea blends, tinctures, medicinal and essential oils, balms, spices, creams, and soaps. All the mentioned products are produced from medicinal herbs from our own production located in the heart of the Deliblato sandstone and by selecting the highest quality species from the network of associates throughout Serbia.

    In addition to direct calls and orders, Chamomilla sells teas and other products online through www.chamomilla.rs.

    Oligo tea mixture therapy acts on a reduced number of sperm and revives existing ones’ movement. The therapy consists of 60 cups of tea with a pleasant aroma and taste. Experience to date has shown improvements in programs after therapy by up to 70%, which results in an approximate number and motility of sperm per milliliter as in normal samples.

    Red meat increases the risk of breast cancer

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    According to the latest studies, women who often eat red meat and red meat products have a high risk of breast cancer.
    Doctors have been warning the general public for a long time that red meat increases the probability that you can get cancer of the intestines or pancreas. Still, so far, it has not been stated that breast cancer is also included.

    In the latest study, Harvard University scientists analyzed data from a sample of 88,000 women between the ages of 26 and 45. The data were filled in a survey in 1991. Their diet and specifically red meat consumption, varied from never less, from once a month to six or more times a day. The initial results were published in 2006 and prove a direct link between red meat consumption and breast cancer, and the latest research has confirmed earlier findings.
    Scientists from this sample conclude that women who used red meat in large quantities out of 1000 subjects had 8 cases more than those who did not use or used red meatless during the analysis.

    In more developed countries where many chemical preparations are used in animal nutrition, women who eat red meat have a 12.5% higher risk of breast cancer.
    Scientists have concluded that proteins in red meat accelerate cell mutation and tumor growth, chemicals such as nitrates in meat products have long been labeled as carcinogenic.
    The study was mostly conducted among educated, white American women, and scientists say that these results are not currently applicable to women of other races. The National Institutes of Health also monitored this survey.

    “This research emphasizes the importance of a healthy diet,” said Sally Greenbrook, a senior official at Breast Cancer Aid in the UK.
    Dr. Valerie Beral, a cancer expert from Oxford University, said that vegetarians have the least chance of getting any cancer.

    Chlorophyll and blood regeneration

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    Chlorophyll is present in most green vegetables, and some take it as a health supplement. Potential benefits of chlorophyll include improved health, increased energy, and disease control.
    Here we consider the possible benefits of chlorophyll and the evidence that supports them. We will also cover ways to take chlorophyll as a supplement.

    What is chlorophyll?

    Chlorophyll is a substance that gives plants a green color. The chlorophyll molecule has a unique ability to convert solar energy into chemical energy (photosynthesis), which plants use to absorb carbohydrates from carbon dioxide and water. After all, all forms of life from the plant and animal world draw energy from their environment, in this case through photosynthesis.

    One of the primary ways to include chlorophyll in your diet is to eat green vegetables, such as alfalfa and spinach. Wheatgrass is especially rich in chlorophyll and is available for purchase online in powder, juice, or capsule form.

    A popular way to include chlorophyll in your diet is to take supplements. They are available in the form of drops, pills, or capsules.

    Most chlorophyll supplements contain chlorophyllin. Chlorophyllin is a water-soluble derivative of natural chlorophyll that is potentially better absorbed by the body than when it comes to other forms of chlorophyll.

    Labels on chlorophyllin-containing supplements may state “sodium copper chlorophyllin” or “copper chlorophyllin complex” in the ingredients.

    Advantages

    People have been using chlorophyll as a health supplement for many years. Various medical studies suggest that it may be useful for skin diseases, body odors, and the fight against certain types of cancer.

    Chlorophyll is generally safe for people to try using if they are interested in its possible benefits. However, anyone who has a health problem or is taking medication should first talk to their doctor.

    Some of the potential benefits of chlorophyll include:

    An anti-aging agent

    anti-aging agent

    Topically applied chlorophyll can be used as an anti-aging agent. Research has shown that applying a gel containing chlorophyllin to the skin reduces the signs of aging that appear due to sun exposure. Skin samples from four healthy women for 12 days were used in the study.

    The study results showed that chlorophyll-treated skin improved similarly to tretinoin-treated skin, a prescription cream that has been shown to help stop the aging process. The authors suggest that using a combination of chlorophyllin and tretinoin could be an effective treatment for changing the signs of aging on the skin.

    Acne treatment

    Local chlorophyll can also have potential as an acne treatment.

    One study showed that a gel containing chlorophyllin helped reduce acne on the head and large visible pores. Ten subjects included in the study had mild to moderate acne and used chlorophyll gel for 3 weeks.

    In another study, a comparison was made using chlorophyll and phototherapy with phototherapy for acne alone. People who received the combination had fewer acne lesions, less severe acne, and less oily skin than those who did not. However, all 24 participants were of Asian descent and darker skin types, so the results may not be relevant for everyone.

    Blood building properties

    blood construction

    Chlorophyll is chemically similar to hemoglobin, a protein needed in red blood cells because it carries oxygen around the body.

    Researchers suggest that wheat juice rich in chlorophyll may help treat hemoglobin deficiency disorders, such as anemia and thalassemia.

    Refresher feature

    Researchers have been researching chlorophyll for its potential as a deodorant for many years.

    A study published in 1960. suggested that chlorophyll could reduce odors in people who had a colostomy. Later, a 1989 survey. Showed that chlorophyll was not effective in controlling odor in people who had a colostomy. However, a 1980 study. Showed that chlorophyll still improves lower body odor in older adults living in nursing homes.

    Today, some deodorants and mouthwashes contain chlorophyll. Some people also take chlorophyll pills to alleviate body odor.

    Help in wound healing

    Researchers examined chlorophyll to aid wound healing during the ’40s and’ 50s. Some of these studies suggest that chlorophyll can heal surgical wounds and prevent infections.

    More recently, testing was conducted in 2008. showed that a drug containing chlorophyll accelerates wound healing and alleviates odors. Some doctors today prescribe this type of treatment.

    Cancer treatment

    Chlorophyll has shown potential for healing cancer in some animal tests:

    • A year-long study showed that chlorophyllin could help prevent and slow cancer growth.
    • 2005 survey found that natural chlorophyll reduces colon cancer risk in rats. Rats ate foods rich in red meat and poor in green vegetables, directly related to the increased risk of colon cancer. However, the authors did not see the same results for chlorophyllin.
    • A study conducted in 2016 showed that chlorophyllin helps slow lung cancer progression in mice. The researchers gave chlorophyllin to mice in microscopic capsules known as nanocapsules.

    Benefits that need more research

    Although chlorophyll has a variety of potential health benefits, there are not enough adequate scientific studies to support them, and all of this requires further investigation. So far, most studies have been small and limited, and many of the potential health benefits are not effective in humans.

    Other possible health benefits that require more research include the effect of chlorophyll on:

    • increase in energy
    • hormonal balance
    • arthritis and relaxation of fibromyalgia
    • weight loss
    chlorophyll

    Chlorophyll and hemoglobin

    Chlorophyll is not such a special biological structure despite its specific function. It is made in a biological form known as the porphyrin ring, which occurs in various organic molecules. A group of these molecules is involved in cellular respiration during oxygen transport and consumption.  One of these organic compounds is hemoglobin, myoglobin, and cytochrome.

    Hemoglobin has a very similar structure to chlorophyll, and it is a substance in human blood whose role is to carry oxygen from the lungs to other tissues and cells in the body. Several studies compare these two substances.

    Chlorophyll around us

    chlorophyll liquid under a microscope

    Can the chlorophyll that is abundant around us increase the body’s supply of hemoglobin, which is a component of our blood that is vital for our survival? This is a beautiful idea. Certainly, some research involving chlorophyll-rich foods to upgrade the blood can be used as a basis for such a statement.

    After an exhaustive review of scientific research that included the relationship between chlorophyll consumption and hemoglobin supplementation in the blood, it was concluded that the relationship between these two compounds is extremely complex than the simple idea that the body will replace the magnesium molecule with an iron molecule to obtain hemoglobin from chlorophyll.

    The exchange of oxygen for carbon dioxide occurs during the circulation of red blood cells. Red blood cells contain the pigment heme, bound to the protein globin, which gives hemoglobin.  Nutrients for maintaining healthy blood include iron, copper, calcium, vitamin C, B-12, folic acid, and pyridoxine.

    Research

    In 1936, Dr. Artur Patek published a fascinating study. Fifteen patients with iron deficiency (anemia) received different amounts of chlorophyll and iron. It is already known that iron alone cures this condition. Still, in combination with chlorophyll, the results were much better. The number of red blood cells and the level of hemoglobin increased significantly and much faster compared to the use of iron itself. Such results were obtained only with the use of chlorophyll.

    Dr. Patek stated the following:

    “This study can encourage us to use this ingredient, which is rich in green plants and green protein foods, and with it, we can fill our depots, which will eventually activate a higher production of hemoglobin in our body.”

    There are real indications that this compound stimulates the synthesis of proteins from which we get the hemoglobin molecule. These proteins obtained from chlorophyll molecules can accelerate the production of depths in our bodies. This may be a key explanation for chlorophyll’s effect on hemoglobin synthesis. “

    Foods rich in chlorophyll

    broccoli rich in hemoglobin

    Most natural green vegetables contain chlorophyll. Among  foods that are especially rich in chlorophyll include:

    • spinach
    • kale
    • mustard
    • chlorella
    • spirulina
    • alfalfa
    • first
    • broccoli
    • cabbage
    • asparagus and peas
    • sword green tea

    In addition to chlorophyll, these vegetables also provide various healthy vitamins and minerals.

    Use of chlorophyll as a supplement

    Chlorophyll supplements vary greatly in potency and formulation. Some supplements come in the form of drops that a person can add to water or another beverage, while others are available in capsule form.

    Packaging containing chlorophyll usually includes instructions on how to use it. If this is not the case, consult a doctor or nutritionist for advice before you start taking it.

    When it comes to liquid chlorophyll supplements, it is recommended to add about 1 teaspoon (5 milliliters) to the drink. If the taste is unpleasant, start with a smaller amount and gradually increase the dose.

    For chlorophyll capsules, the recommended dose is in the range of 100 to 300 milligrams up to three times a day.

    Chlorophyll supplements are generally safe to use and do not seem to have serious side effects. However, pregnant and breastfeeding women should talk to a doctor before taking chlorophyll in a supplement.

    Some people may notice stomach upset or skin irritation after taking chlorophyll. People who experience disturbing side effects must stop taking the supplement and visit a doctor.

    Conclusion

    Chlorophyll has various potential health benefits, but the evidence for most of these is not enough, and more research is needed.

    Some people may find that including more chlorophyll in their diet or taking supplements makes them better or helps with medical conditions, such as anemia.

    There are many reasons why green plants should be included in foods that enhance the blood picture structure. Vitamins and minerals in this kind of food are essential during the synthesis and construction of healthy blood.

    The connection and similarity between green food and blood and the structure of the two colored pigments, hemoglobin, and chlorophyll, are fascinating. Although investigated in the last 60 years, the biological connection between these two molecules is not completely clear.

    However, it has been shown that small amounts of chlorophyll absorbed in the digestive tract can stimulate the production of heme or depths in both humans and animals.

    Always consult your doctor about supplements, including chlorophyll, before using them.

    Hormonal imbalance – Chronic stress is the most common cause of health problems

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    “If you really knew what was happening to you when you were under stress, you would totally go crazy. Then some horrible things happen “- this is my statement during a scientific conference, and I was not joking when I said this. I can write several books on how stress causes massive chaotic reactions in your body.

    If you want to avoid stress, you were born at the wrong time. Chronic stress has become an epidemic in a society where the faster, the better we try to pack too many responsibilities into our schedule.

    Hormones and stress

    hormonal imbalance and stress

    In all this chaos, one analysis involving 300 studies proved that chronic stress could harm your immune system. And that’s not all,  because a large dose of stress makes you fatter and affects the development of diabetes.

    Scientists have known for a long time that stress causes higher blood sugar levels and also increases obesity. When the body is under chronic stress, insulin levels rise. This condition leads to metabolic dysfunction, which increases body weight. Over time, the body becomes resistant to insulin and, of course, diabetes.

    When you are under stress, your adrenal gland releases hormones such as adrenaline and cortisol that overwhelm your body, increase your heart rate, increase blood pressure, increase blood density, and create blood clots, creating damage to the brain memory center increasing body weight. And generally creating chaos in your body.

    Food and hormonal disbalance

    food for the thyroid gland

    This hormonal imbalance, as we see, creates negative consequences. For example, you stop to drink coffee in your favorite cafe on the way to work. Frozen in front of millions of requests and traffic jams, you realize that you haven’t had breakfast at all. You order a donut with coffee.

    Looking at breakfast’s seemingly harmless situation, caffeine from coffee increases catecholamines, stress hormones. In response to stress, the body produces cortisol, which together with sugar increases insulin. Insulin increases inflammation, and this affects the complete condition of your body. Donut sugar increases cortisol and adrenaline, stress hormones. Sugar literally creates an explosion of stress hormones even though you are not under stress.

    There is a good chance that he will continue to consume this type of food during the day. In that way, perfect conditions are created for hormonal imbalance, which leaves behind fatigue, unhappiness, and large fat deposits.

    The right diet can reduce the impact of stress on your life and your body. When you eat whole, real food, you return the body’s resistance to insulin, cortisol, and other hormones to normal.

    When you cleanse your diet of foods, you are addicted to, such as caffeine, alcohol, sugar derivatives, and regularly eat healthy foods to avoid short-term hunger stress, you will be able to maintain your body in a lower daily dose of stress.

    If you replace this food with pure proteins, healthy fats, leafy vegetables, berries with many grains, and less gluten, you feel much better. Food is information that controls the expansion of genes, hormones, and metabolism. When you eat the right foods, you regulate your blood sugar level, restore balance to the hormonal system and reduce stress-induced damage.

    Source stress

    Stress is a real threat, although it is not real and tangible. If so, we should have complete control over stress because it does not happen outside, but it is inside us.

    The definition of stress is as follows:

     “Stress  is a set of non-specific reactions of the human body to harmful factors from the work and living environment. Harmful factors from the human environment activate  adaptation mechanism  in the body to organism  protected by balancing the environment. “

    Things get even more interesting here.  You can imagine your husband being mad at you. Regardless of other circumstances, your stress level will rise. However it works, the body creates a certain body response to certain external information.

    Most people, when they focus on my life and analyze it, think I’m crazy and always ask me why I’m not stressed even though I’m constantly surrounded by dissatisfied people, even though I run a massive research campaign in various scientific fields, even though I’m opening a new clinical center. I am under constant obligations when procuring new means of work and discovering new technologies and treatment preparations. However, I am involved in improving health policy in our country and practical work with people and father, son, brother, partner, friend, boss, and many other roles in his life. The answer is actually straightforward. Don’t worry about things much. I wake up and do each new task the best I can.

    Causes of the presence of stress

    stress relief meditation

    I manage these responsible responsibilities that I have listed with several techniques that help me get rid of stress. Among them, these 12 are my favorites.

    1. Lack of magnesium, vitamin b12, increased mercury and aluminum levels, and gluten allergy can directly affect stress levels. By changing habits, you can change the state of your mind.

    2. People are burdened to do something all the time. Even though you are not working, your mind is still functioning. Learn how to rest actively. To rest the powerful forces of mind and body, you must do something relaxing. You can sit and watch TV or read a book. You can breathe deeply or take a leisurely walk. It is important to find the type of relaxation that suits you.

    3. Learn new skills such as yoga or progressive muscle relaxation, take a bath, make love, go for a massage, watch the sunset or take a walk in the woods or on the beach.

    4. Exercise is a powerful, proven way to burn and flush stress chemicals out of your body and calm your mind. Studies have shown that exercise achieves much more than some medications to cure depression. Try workouts with strong intensity if you have little time and want a good result.

    5. Take multivitamins and dietary supplements to help your body, vitamin c, b complex, zinc, magnesium.

    6. Take various herbs such as Siberian ginseng, cordyceps, ashwagandha.

    7. Use a steam bath or sauna to help your body get rid of toxins and relieve stress.

    8. Examine your reactions and behaviors, responses in certain situations, and adjust to reduce stress.

    9. Continuously build a network of friends and your harmonious community. You will need many allies to establish your harmonious balance.

    10. Most of us have shortness of breath. Deep and slow breathing has a profound effect on reducing the body’s response to stress because the relaxation nerve passes through the diaphragm and is activated when you take a deep breath. Take a deep breath now and see how you feel different the next moment.

    11. Meditate with exercises that suit you.

    12. Get enough sleep because lack of sleep increases stress hormones.

    Thyroid gland – 6 ways to improve its function

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    The thyroid gland plays a key role in your metabolism. Along with insulin and cortisol, your thyroid hormone is one of three hormones that control metabolism and body weight.

    Treatment thyroid glands

    Proper testing determines whether slowed thyroid function contributes to metabolic arrest and encourages other body problems. Once the right information is obtained, it can be helped through various ways in eliminating thyroid problems.

    One young patient had more than 30% fat in his body, and no matter how hard he tried, he could not change this condition. Although he introduced a perfect diet, although he exercised every day, he did not show any signs of progress. This person was also very pronounced with symptoms of depression.

    The person was treated with low doses of thyroid Armor ® natural thyroid hormone substitutes.

    This man lost about 10 kilograms and improved his organism and mood. He also got rid of other symptoms.

    How did he have such a low level of thyroid function? I asked him questions related to the symptoms. We examined the organism’s condition, and we identified potential problems caused by the poor functioning of the thyroid gland. Then I did a real test.

    Functional medicine and thyroid hormone tests

    Most doctors check something we call thyroid-stimulating hormone or TSH, which doesn’t really give a true picture of the thyroid gland. More precisely, the interpretation of this test is incorrect in most cases.

    According to the latest guidelines, a person who has a score over 3 is considered a patient who needs some treatment. Most doctors believe that results over 5 or 10 should be treated, which leaves many people suffering from this health problem without proper treatment.

    Near TSH, functional medicine also performs other t3 and t4 tests and a thyroid antibody test. We also test for gluten intolerance, food allergies, heavy metals, and also a deficiency in such cases: vitamin D., selenium, vitamin A and omega 3 acids.

    In the following text, I would like to deal a little deeper with the thyroid gland’s problem and the strategies of treatment.

    An integrative approach is needed to correct these problems. There are more methods involved in solving this problem than just taking a few pills during the day. As you will see, this includes nutritional support, exercise, stress reduction, inflammation reduction, and sometimes the elimination of certain foods and detoxification of heavy metals such as mercury and lead, and petrochemical toxins.

    To integrate all of these elements into a successful set of techniques for treating your thyroid, I recommend the following 6 strategies:

    Strategy 1: Eliminate the causes of thyroid problems

    Carefully consider what things can interfere with thyroid function and eliminate them. As you will see, many things can interfere with the thyroid gland’s optimal function.

    Diet is a good start. Some foods have developed a terrible reputation for affecting thyroid function. These facts are, in many cases, not supported by relevant scientific research.

    For example, food rich in soy, food from the family broccoli cause thyroid problems, so medicine claims. In one study, rats fed exclusively on soy had problems with their thyroid gland.

    The following message should be drawn from this: if you are a rat, stay away from tofu. Clinical trials have proven that soy creates an optimal effect on people when consumed in normal amounts.

    Thyroid gland and allergies

    arteries of the thyroid gland

    On the other hand, there are groups of substances that support autoimmune diseases thyroid glands and slow down metabolism.

    One of them is gluten. If you think you have a thyroid problem, what you need to do is a blood test in which any hidden reaction to gluten found in wheat, barley, rye, oats should be discovered. Gluten sensitivity or allergies can cause various symptoms, from migraines and fatigue to weight gain.

    In addition to a blood test, you can easily eliminate gluten from your diet for three weeks. If your symptoms go away, you have solved one of the sources of your thyroid problems. If you want to go a step further, re-incorporate gluten into your diet to see if symptoms recur. If this happens, it is a significant detail.

    There are other food allergies besides gluten that disrupt the thyroid gland’s functionality. By cooperating with your doctor, you should eliminate food allergies.

    In addition to certain foods and food allergies, toxins can also slow down the thyroid gland’s function. By testing for heavy metals, you can determine if a source in your environment may be critical to your current condition. Fluoride, associated with thyroid problems, and chlorinated water should be avoided.

    Checking for pesticides is much more difficult, but it is possible to detoxify the body to these compounds by eating organic food, filtering your water, and increasing your detox food intake. This way, you will help your thyroid gland get rid of another factor affecting its functionality.

    How to cure allergies and influence them to combat their aggressive action. You can read 9 ways to prevent an attack on yourself in the text.

    Thyroid gland and stress

    Stress has a very negative effect on the functioning of the thyroid gland. Military cadets subjected to intense stress during training had higher cortisol levels, higher levels of inflammation, lower testosterone levels, higher TSH, and very low T3.

    The usual form of chronic stress causes exhaustion of the adrenal gland, one of the possible causes of hypothyroidism. Adrenal exhaustion occurs when the adrenal gland is no longer able to meet the physiological needs created by stress.

    To get rid of stress, it is necessary to relax the organism, for which there are various methods.

    You can read more about the impact of stress on our body in the article on how stress causes hormonal chaos.

    Strategy 2: Regular exercise and saunas

    Exercise stimulates the secretion of the thyroid gland and increases tissues’ sensitivity to thyroid hormones. Ideally, you will sweat a lot during intense exercise.

    In addition to being a great way to relax your muscles and mind, you can expel large amounts of toxins from your body in saunas and steam baths. Saunas are an essential aid to the body in losing weight, reducing body fat, and expelling accumulated toxins such as PCBs and organic origin pesticides. Excretion of toxins lowers the level of T3.

    For proper functioning, the thyroid gland requires detoxification if detoxification is not done, your ability to lose weight decreases due to the influence of accumulated toxins on the thyroid gland’s function.

    Strategy 3: Eat foods that promote a healthy thyroid gland, eliminate foods that are harmful

    food for the thyroid gland

    Every step on the path to healing and weight loss depends on nutrition and food use to properly establish balance in the body. Thyroid treatment is no exception.

    Choose foods that support your thyroid’s metabolism. The production of thyroid hormones requires iodine and omega 3 fatty acids. Selenium is needed to convert inactive T4 to active T3, vitamins A and D are needed to bind T3 to receptors on the nucleus, and zinc. To get the full therapeutic value of these nutrients, use the supplements from Strategy 4.

    Foods to improve thyroid function are seaweed and iodine-containing seafood. Fish (especially sardines and salmon) contain omega 3, iodine, vitamin D. Dandelion, mustard, and other greens containing vitamin A, herring, shellfish, and Brazil nuts contain selenium. If you want to avoid foods that interfere with thyroid function, you should eliminate foods rich in gluten, you should use pure soy and soy proteins in moderate amounts, and you should avoid processed soy products.

    Strategy 4: Use supplements that support the work of your thyroid gland

    The main supplements for healthy thyroid function are multivitamin and multimineral complexes containing selenium (sodium selenite), iodine, zinc,  vitamins A and D, and omega 3 fatty acids.

    Iodine can be obtained naturally or by using supplements:

    Kelp algae

    Iodine drops

    Sodium selenite

    You can also read good information on how you can treat your thyroid gland with kelp in the article Effects of kelp on the thyroid gland

    If your adrenal gland is exposed to stress for a long time, it is impossible to treat the thyroid gland without supporting the adrenal gland with adaptogenic plants such as ginseng, Rhodiola, or Siberian ginseng.

    We recommend working with an experienced nutritionist who will guide the diet and intake of certain nutrients that your thyroid gland and, if necessary, your adrenal gland need.

    Strategy 5: thyroid testing

    thyroid gland veins

    There is no perfect way, neither symptoms nor test results, by which we will correctly diagnose low thyroid function or hypothyroidism.

    The correct way is to look at the complete picture of symptoms and blood tests and then decide.

    Doctors usually diagnose thyroid changes by testing TSH levels and T4 levels. Some doctors have questioned the normal levels of these two parameters.

    The diagnosis of “subclinical” hypothyroidism depends on TSH levels, which should be greater than 5 m IU / ml and less than 10 m IU / ml in the event of a disorder. As I mentioned in the previous text, the new measurements show that anything over 3 m IU / ml is abnormal. As long as the parameters are within these limits, many doctors will miss this diagnosis segment, and many ill people will not be treated properly.

    To get a complete picture, I recommend observing the following range of functions:

    TSH should be ideally between 1 and 2 m IU / ml

    Free T4 and free T3 (inactive and active hormone)

    Thyroid antibodies search for autoimmune reactions, which generally remain undiagnosed if other tests are normal and if the doctor does not perform a routine examination of this parameter.

    TRH stimulating test

    A 24-hour urine test for free T3 that may be helpful in cases that are difficult to diagnose.

    Based on these tests, an experienced doctor can get more information about how your thyroid gland works.

    If you think you have not been diagnosed with a thyroid problem, ask your doctor to do these tests or find a doctor who will do them. They are essential when putting together a puzzle of your diagnosis that standard tests do not provide.

    Strategy 6: Choose the right thyroid hormone replacement

    To balance the thyroid gland that has been thrown out of balance, you will need thyroid hormone therapy.

    By changing your diet and lifestyle, you will certainly improve your thyroid gland’s condition. Still, if the thyroid gland is not functioning, you will have to take some additional measures to supplement the production of thyroid chromones.

    In my medical studies, I learned about Synthroid ® synthetic form of T4.

    Why do doctors give this medicine? For that reason, he is the only one they know how to copy. But is this the only good treatment for everyone? In some people, it is effective, but the symptoms remain present to the same extent in some people. What exactly is the right treatment, then?

    The answer is, it depends on the person.

    Part of functional medicine’s truth is that no treatment can be functional for everyone. By combining experience, testing, testing, and even the mistakes we see, we achieve the right treatment.

    Medications for thyroid problems

    At the same time, I have found that most of my patients have a very positive reaction to the combination of T3 and T4 hormones. Synthroid® represents only T4, an inactive hormone. Many doctors believe that the organism itself will pick it up in T3 and that everything will be fine.

    Unfortunately, pesticides, stress, mercury, infections, allergies, and selenium deficiencies block this process. While 100 percent of patients have pesticides stored in the body, mostly everyone will have a problem with this process and Synthroid ®.

    The best treatment I use is Armor thyroid medicine, obtained from a dried pig’s thyroid gland. This preparation contains a full spectrum of thyroid hormones, including T4, T3, and T2. The last T2 is a little-known thyroid metabolism product, which can be very significant. Its dosage varies between 15 and 180 milligrams, depending on the person.

    Many doctors have an outdated belief that such preparations are unstable and that dosing is complicated to monitor. Such is the case with the old Armor preparation, not with the new preparations.

    One of the potentially good supplements that I can recommend to people who suffer from thyroid dysfunction and with which they can increase the metabolism of transforming T4 into T3 automatically and increase T3 is the T100 preparation, which can also stabilize the weight gain process. T 100 has shown remarkable results in thyroid problems.

    After several decades of working in functional medicine, I can freely say that you can cure your thyroid gland even in the most severe cases. In some patients, this can be achieved through proper diet and dietary supplements, and lifestyle changes. In others, the use of some drugs is required under the expert supervision of a medical professional.