Artemisinin derivative of sweet wormwood and its growing importance in medicine

artemisinin as a malaria drug

Artemisinin is obtained from the extract of sweet wormwood and has so far been found to be excellent for the treatment of malaria including highly resistant strains of this parasite.Its effectiveness  has also been shown in parasitic infections such as schistosomiasis. Sweet Pelin has shown great influence and broad properties in carcinogenic diseases and tests have been performed on animals and humans.

Progress in defining the role has been seen in many ways and from various angles artemisnina in medicine, with a special focus on its mechanisms and mode of action. This safe and inexpensive drug that saves the lives of people infected with malaria can also have significant potential in oncology.

Artemisinin’s introduction

The story of Fr. I will discover sweet wormwood and its active ingredient artemisinin by Chinese scientists, which is one of the greatest discoveries in medicine in the second half of the 20th century. This project is called 523 and they were discovered on that occasion dihydroartemisinin , artemether, artelic acid or generic known as artemisinin which is now making incredible strides in the treatment of malaria. Malaria is so prevalent that we have about 500 million new cases each year. This drug differs in many properties from the classic quinoline anti-malarial drugs and is extremely effective when combined with them.

Structure of artemisinin derivative of sweet wormwood:

(AND) Artemisinin isolated in crystal 1973 from the plant artemisia annu or sweet Pelin ,, (B) dihydroartemisinin, (C) arthemer, (D) artesunat, (F) arter were first discovered by Chinese scientists in 1970. (  E) Artemisin is a representative of a new class of artemisinin known as amino-artemisinin. Its characteristics are low toxicity. (G) Artelinate is prepared as a product in Walter’s Red Army Institute for research but was rejected and the research was discontinued due to its high toxicity. (H) Deoxyarthemisinin.

Artemisinin  is the subject of many studies aimed at researching and improving this class of drugs. Artemisnini are also active against other parasitic species, including protozoa, which are a phyogenetic species of parasite associated with malaria-causing plasomodium parasites. Artemisinin derivative of sweet wormwood also acts against the metazoan parasite Schistosomes. Their healing effect also includes a strong anticancer effect. Many reports from medical studies show artemisinin as an anticancer agent. Recently, a clinical study was published in patients with lung cancer, and during the short-term use of this cheap preparation, it was determined that there are valid reasons to include this drug in the integral part of anti-cancer therapy.

Use of artemisinin to treat malaria

Use of semi-synthetic derivative artesunate from sweet wormwood for the treatment of severe malaria has been highlighted in recent publications. Artesunat is very effective compared to quinine and has fewer side effects than quinine, the only drug used to treat malaria.

Mortality in adults with artesunate is lower than in quinine. Intractal treatment has been studied extensively in adults and children with malaria symptoms who are very far from health facilities. New results from these studies will be available soon. Safety and efficacy are very important in these studies. However, one child treated with very high doses of artesunate 88 mg / 1kg compared to the permitted 10-20 mg / 1kg died during treatment from the toxicity of this drug.

It should be emphasized that artesunat is much more toxic than artemisinin, but it acts faster. Interestingly, oral artemether and DHA are commonly used in multidose formulations instead of artesunate. Artesunat may have positive properties, both in terms of stability and ease of action compared to DHA but also in negative effects in animals when compared to artemether. New semi-synthetic artemisinins such as artemisinin are not only safe but also improve efficacy and have an improved effect against malaria models that have acquired resistance to artemisinin.

Anticancer properties of artemisinin – sweet wormwood

Video with the lead

Artemisinin’s anti-cancer properties have been tested since the late 1980s. After detailed studies, artemisinin was found to be active against many tumor lines, including the most common types such as colon, breast cancer, lung cancer and leukemia, and pancreatic cancer. Studies have also identified general mechanisms in the normalization of certain metabolic processes in the body that cause artemisinin.

Other mechanisms of anticancer activity include inhibition of enhanced tumor-associated anginogenesis. Artemisinin inhibits the proliferation, migration and formation of tubes from the human umbilical vein of endothelial cells, inhibits vascular endothelial growth factor. In cancer cells, artemisinin reduces the expression of VEGF receptors and slows the growth of human ovarian cancer.

It has also been proven that in some cancerous diseases, the delivery of larger amounts of iron increases the efficiency of artemisinin. Should I artemisinin remains one of the few compounds that have not been sufficiently researched and have interesting properties in the treatment of cancerous diseases? Of course not, and there are many reasons for that. First artemisinin is inexpensive, safe, and easily taken orally as a bioavailable compound that targets many types of cancer.

Animals have been tested and shown that artemisinin has antitumor activity and reduces the risk of developing liver metastasis. In addition, clinical trials of individual cases recently published in lung cancer studies prove that artemisnin in this case, it is extremely effective in antitumor intervention, and this is especially pronounced in colorectal cancers and leukemia.

Dr. Michael Lam wrote a very good article about research on sweet wormwood and its application in medicine  you can find more information about their research  here

Other potentially useful properties of artemisinin and its compounds

In new studies, it was discovered in several groups artemisinin it also has antiviral properties. Artemisinin reduces the replication rate of hepatitis B and C, herpes, HIV-1, influenza A virus and bovine viral diarrhea. Artemisinin is also effective in reducing human herpes virus 5 when used at 300 mg daily for 30 days orally. Artemisinin it also has some antifungal properties against pneumocisitis customs. There are several other positive effects on diseases such as rheumatoid arthritis , renal syndrome, pencreatitis.

Artemisnin is firmly established as a cure for malaria in combination therapies. Its great potential now lies in diseases that are a challenge for all of humanity, such as many cancers, and for which there are currently only effective expensive treatments. The issues are, of course, the dosing regimen, the safety of long-term use and the possibility of indications with combination therapies. These are needs that need to be urgently explored in clinical studies for a past and future drug called artemisinin.

You can read more about the use and use of artemisinin and methods of treating cancerous diseases here